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Revista Española de Enfermedades Digestivas
Print version ISSN 1130-0108
Abstract
ROGER, Manuela et al. EUS-FNA cytological material from pancreatic lesions: the expression of cathepsins and its predictive value of malignancy. Rev. esp. enferm. dig. [online]. 2018, vol.110, n.7, pp.446-450. ISSN 1130-0108. https://dx.doi.org/10.17235/reed.2018.4200/2016.
Aims:
To assess the expression of cathepsins in pancreatic samples obtained by endoscopic ultrasonography and fine needle aspiration (EUS-FNA) and to investigate their relationship with the staging of the pancreatic ductal adenocarcinoma (PDAC).
Methods:
We prospectively included patients with solid pancreatic masses, in which EUS-FNA were performed. Cathepsins B, L, S and H expression was determined in FNA samples.
Results:
Seventeen FNA were performed. All cytological material was from PDAC. Expression of cathepsins was predominantly low (B 65%, L 23%, S 76%, and H 41%). We found no correlation between the expression levels and the extension of the neoplasm.
Conclusion:
Expression of cathepsins in the cytological material of PDAC is diverse but still poor to be useful in the pre-operative diagnosis. There is no correlation between the expression levels of cathepsins and the extension of the PDAC.
Keywords : Pancreatic neoplasms; Cathepsins; Endoscopic ultrasonography.
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