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Revista Española de Cirugía Oral y Maxilofacial

On-line version ISSN 2173-9161Print version ISSN 1130-0558


GOMEZ OLIVEIRA, G.; FERRERAS GRANADO, J.  and  JUNQUERA GUTIERREZ, L.M.. Spindle cell carcinoma of the oral cavity: A review of 9 cases. Rev Esp Cirug Oral y Maxilofac [online]. 2006, vol.28, n.1, pp.43-50. ISSN 2173-9161.

Spindle cell carcinoma is a malignant and rare variant of squamous cell carcinoma. The histological pattern is composed of a double cell proliferation: a sarcomatous component made up of spindle-shaped cells and a carcinomatous component made up of epithelial cells. Nearly all the anatomy of the body can be affected by these tumors although the most common location is the upper aerodigestive tract. With regard to sex distribution, it is more frequent in males than in females in their sixth and seventh decades of life. Its behavior is aggressive and it tends to recur after treatment. The most important risk factors are alcohol and tobacco. The histological diagnosis is complicated, so immunohistochemical techniques and the use of electron microscopy are usually necessary. Nowadays, its epithelial origin is accepted. The aim of this article is to report a retrospective study of 9 cases of oral cavity spindle cell carcinoma treated in our service of Oral and Maxillofacial Surgery, between 1985 and 2004. We describe the clinical behavior and the pathogeny of this tumor.

Keywords : Spindle cell carcinoma; Oral cavity; Immunohistochemical; Biphasic tumor; Squamous origin.

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