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Revista Española de Cirugía Oral y Maxilofacial

On-line version ISSN 2173-9161Print version ISSN 1130-0558


GIL CARDENAS, Fermín; OSORIO DAGUER, María del Rosario; FORTICH MESA, Natalia  and  HARRIS RICARDO, Jonathan. Bone regeneration in mandibular third molar dental sockets of smokers using platelet rich plasma. Rev Esp Cirug Oral y Maxilofac [online]. 2018, vol.40, n.2, pp.71-77. ISSN 2173-9161.


The aim of this study was to evaluate bone regeneration in the dental sockets of smokers using platelet-rich-plasma (PRP) as an adjuvant.

Materials and method:

A quasi-experimental intervention study of two groups (experimental and control) in whom teeth number 38 and 48 were extracted. PRP was not applied in the control group, but it was applied in the experimental group using the single centrifugation method in the socket of tooth 38, and with double-centrifugation PRP being applied in the socket of tooth 48. Radiography follow-up was performed at 8, 30, and 60 days after the surgery in order to evaluate the bone density. A univariate and bivariate descriptive analysis and Student-t test were performed.


Of the 19 subjects that took part in the study, 52.6% were male. In the bone density study using the three radiographic controls at 8, 30, and 60 days, no statistically significant differences (P>.05) were found in the experimental group in the sockets of tooth 38 and 48, but there was a slight improvement in the healing of socket 48 where PRP was used with the method of double centrifugation. On comparing the follow-up x-rays of the control with those of the experimental group, statistically significant values were found in the group where PRP was applied using the single or double centrifugation method (P<.05).


The bone regeneration process is more favourable in those smokers on whom PRP was applied than in those where it was not applied. No statistically significant difference was observed in the bone regeneration process applying PRP using the single or double centrifugation method.

Keywords : Platelet-rich plasma; Bone regeneration; Smoking.

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