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Farmacia Hospitalaria
On-line version ISSN 2171-8695Print version ISSN 1130-6343
Abstract
OYAGUEZ, I. et al. Efficiency of oncologic treatments for solid tumours in Spain. Farm Hosp. [online]. 2013, vol.37, n.3, pp.240-259. ISSN 2171-8695. https://dx.doi.org/10.7399/FH.2013.37.3.570.
Objective: To provide estimates of the efficiency for chemotherapy strategies used in Spain. Methods: Published reports of the phase-Ill clinical trials for chemotherapies used for the most prevalent solid tumours in Spain were retrieved. The incremental cost-effectiveness ratio (ICER) was calculated for each strategy compared to the control group in the clinical trial, with the National Health System perspective. The total cost (€, 2012) including only drug cost (ex-factory price) was estimated based on the total units of each drug required for administration (no vial wastage), with the dosification and number of cycles specified in the publication for each treatment arm. Effectiveness was measured as month of overall survival (OS) and/or month of progression free survival (PFS). Results: A total of 40 chemotherapies for 13 different advanced or metastatic tumours were assessed. OS ranged from 5.3 to 33.3 months for the 34 therapies that included the information with hazard ratios (HR) values from 0.49 to 1.15 when compared with its control group. PFS ranged, from 39 therapies with these data, between 1.5 to 12.4 months, with HR from 0.33 to 1.52. ICERs were between €2,142.57 and €60,996.37 per each OS month gained, and from €2,102.54 to €661,845.27 per PFS month gained. Conclusion: The variety and heterogenicity of survival and ICERs results, suggest disparity of criteria in the price and reimbursement process of drugs in Spain. The continuous advances in oncology seem to require economic revaluations of drugs.
Keywords : Efficiency; Neoplasm; Antineoplastic protocols; Cost-effectiveness; Survival.