SciELO - Scientific Electronic Library Online

vol.41 issue2Assessment of the efficacy and safety of fampridine author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google


Farmacia Hospitalaria

On-line version ISSN 2171-8695Print version ISSN 1130-6343


MONSALVE-NAHARRO, José Ángel et al. Inhaled nitric oxide in adult patients with acute respiratory distress syndrome. Farm Hosp. [online]. 2017, vol.41, n.2, pp.292-312. ISSN 2171-8695.

In some patients, acute respiratory distress syndrome (ARDS) leads to life-threatening refractory hypoxemia developing. Physicians may consider hypoxemic rescue therapies in an attempt to improve oxygenation in these patients while on conventional mechanical ventilation support. Use of inhaled nitric oxide (iNO) in ARDS is one of the most widely-studied pharmacological interventions over the past two decades. Its efficacy was examined in several randomized clinical trials and has undergone meta-analyses. Although iNO treatment was associated with improved oxygenation, researchers unfortunately never demonstrated a concomitant decrease in mortality or any improved outcome. Hence the current evidence suggests that iNO should not be routinely used in patients with ARDS however may be considered as adjunct therapy to tentatively improve oxygenation while other therapies are being considered in patients with severely hypoxemic ARDS.

This review focuses on the therapeutic use of iNO in adult ARDS patients. We set out some recommendations for its use as rescue therapy against refractory hypoxemia.

Keywords : Acute respiratory distress syndrome; Acute lung injury; Hypoxemia; Nitric oxide.

        · abstract in Spanish     · text in English | Spanish     · English ( pdf )