SciELO - Scientific Electronic Library Online

vol.41 issue4Assessment of off-label prescribing: profile, evidence and evolutionImpact of an antimicrobial stewardship program on critical haematological patients author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google


Farmacia Hospitalaria

On-line version ISSN 2171-8695Print version ISSN 1130-6343


ROBUSTILLO CORTES, María de las Aguas; ALMEIDA GONZALEZ, Carmen Victoria  and  MORILLO VERDUGO, Ramón. Relationship between pharmacotherapy complexity and patient satisfaction with treatment for hepatitis C. Farm Hosp. [online]. 2017, vol.41, n.4, pp.470-478. ISSN 2171-8695.


To establish the relationship between the complexity of treatment for hepatitis C and patient satisfaction.


An observational, prospective, single-center study, which included HCV patients treated between October 2014 and February 2016.

The primary endpoint was the assessment of satisfaction with treatment, measured by the HCV-ESTAR questionnaire, structured into two dimensions: clinical and lifestyle satisfaction, on a 0-60 score. A reliability analysis was performed.

The data collected were: treatment prescribed for HCV, concomitant medication, and Sustained Viral Response. The complexity index of the complete pharmacotherapy was calculated by the computer application MRCI.

T-Student was used to identify the complexity of treatment as a marker of dissatisfaction.


The study included 171 patients (83.0% male). The mean satisfaction score was 47.9±7.5. The reliability of the complete questionnaire was high (Cronbach alpha, 0.864; intraclass coefficient, 0.843). There was correlation between the Complexity Index and satisfaction (P<0.05). A reduction of 5 points in the Complexity Index increased fourfold the value of satisfaction with treatment (p<0.0001). Similarly, a reduction in 12 points in the Concomitant Medication Index doubled the satisfaction (p=0.028). Regarding the overall complexity, 10 points less doubled the satisfaction (p<0.05).

Finally, patients with higher values of satisfaction presented a higher response rate (p=0.029).


An increase in pharmacotherapeutical complexity has an impact on satisfaction, and at the same time, on achieving Sustained Viral Response.

Keywords : Pharmaceutical Care; Hepatitis C; Satisfaction; Medication Complexity Index.

        · abstract in Spanish     · text in English | Spanish     · English ( pdf )