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Farmacia Hospitalaria
On-line version ISSN 2171-8695Print version ISSN 1130-6343
Abstract
GONZALEZ-GARCIA, Jonathan; GUTIERREZ-NICOLAS, Fernando; NAZCO-CASARIEGO, Gloria Julia and VINA-ROMERO, María Micaela. Long-term stability of trastuzumab in plasma and whole blood samples stored under different conditions. Farm Hosp. [online]. 2019, vol.43, n.2, pp.50-52. ISSN 2171-8695. https://dx.doi.org/10.7399/fh.11110.
Objective:
The present work analyzed the stability of trastuzumab concentrations in blood and plasma samples stored at 4 °C and -20 °C.
Method:
Blood samples of patients treated with trastuzumab (Herceptin®) were analyzed. Stability of trastuzumab was analyzed under different conditions: whole blood stored at 4 °C during 72 hours, blood plasma stored at 4 °C during 120 hours and blood plasma stored at -20 °C during 365 days.
Results:
In whole blood trastuzumab concentration at 72 hours was 99.01 ± 0.02%, and in plasma samples at 120 hours it was 98.6 ± 2.0%. The concentration of trastuzumab was 95.22 ± 3.20% after 12 months’ storage at -20 ºC.
Conclusions:
The concentration of trastuzumab remains stable for at least 72 hours in whole blood stored at 4 °C, five days in plasma stored at 4 °C and one year in plasma stored at -20 °C.
Keywords : Blood plasma; Blood serum; Stability; Storage; Trastuzumab.
