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Farmacia Hospitalaria

versión On-line ISSN 2171-8695versión impresa ISSN 1130-6343


RODRIGUEZ-DE FRANCISCO, Lupe et al. Validation protocol of the LESS-CHRON deprescription tool in multimorbidity patients. LESS-CHRON-VALIDATION Project. Farm Hosp. [online]. 2022, vol.46, n.5, pp.311-315.  Epub 19-Dic-2022. ISSN 2171-8695.


Deprescribing is considered one of the main strategies available for preparing an individualized therapeutic plan in patients with multiple pathologies or complex chronic conditions. However, despite the practice has been in place for some years, there is a need for studies that support the achievement of satisfactory health outcomes, as well as tolos that help implement deprescribing in routine clinical practice. The objective of this project is to analyze the impact of reducing polypharmacy, through the LESS-CHRON deprescribing tool, on a population of elderly polymedicated patients with multiple conditions.


This will be a quasi-experimental, pre-and-post intervention multicenter cohort study. The variables to be analyzed will be divided into two large groups: those related to pharmacology and those related to health outcomes. They will be collected at baseline, at 3 and at 6-12 months. A first screening phase will be carried out to recruit candidate patients and obtain information about the identified deprescribing opportunities. The second phase will constitute the intervention phase, where the LESS-CHRON tool will be applied and the actual deprescribing of the drugs will be carried out.


LESS–CHRON has been proclaimed as a suitable deprescribing tool in clinical practice. Validation of LESS-CHRON will seek to show the results that can be achieved following the deprescribing of drugs, in addition to demonstrating that the tool can reliably be used by clinicians in their routine practice. On the other hand, the results of this project may provide information leading to improving or adapting the tool itself, giving rise to a second generation of more efficient versions.

Palabras clave : Deprescribing; Multimorbidity; Polypharmacy; LESS-CHRON; Chronic disease.

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