Abstract

TORRE, F.; GOMEZ-VEGA, C.; CALLEJO, A.  and  GENOLLA, J.. Samarium-153-Lexidronam (EDTMP) for the management of bone metastases. Rev. Soc. Esp. Dolor [online]. 2004, vol.11, n.1, pp.15-20. ISSN 1134-8046.

Bone metastases are a frequent complication in cancer patients. Bone tissue ranks third, after lung and liver, of all the organs and systems with metastases. Approximately 75 per cent of patients with bone metastases will suffer pain, this being the most frequent cause of pain in cancer patients. Bone pain increases with movement and pressure, restricting patient autonomy and quality of life. The treatment includes several complementary therapeutic regimes: NSAIs, opiates, biphosphonates, radiotherapy, radioisotopes, surgery and invasive techniques. We present two clinical cases. The first is a women diagnosed of breast carcinoma and the second, a man with prostate and bladder carcinoma, in both cases with bone metastasis dissemination. The persistence of pain and its difficult management determined in both patients the administration of Samarium-153 Lexidronam (Quadramet). Pain and opiates consumption decreased, despite the progression of the disease. Sm-153 is a radioisotope with emission of beta and gamma radiation. It has a short physical half-life, high affinity for the bone and renal excretion. Pain relief is about 65-80%, with fast and sustained analgesia that lasts 8-12 weeks and minimal side effects.

Keywords : Pain; Bone metastases; Samarium-153.

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