Abstract

CALDERON, E. et al. Associated sexual dysfunction to the use of gabapentin in the treatment of the central pain. Rev. Soc. Esp. Dolor [online]. 2006, vol.13, n.5, pp.300-302. ISSN 1134-8046.

The neuropathic central pain, is one of the more complex painful syndromes, its treatment is difficult and, in general, little satisfactory. Gabapentin (GBP), it is a anticon-vulsant used in the treatment of the epilepsy, neuropathic pain, disorder bipolar, and it is generally well tolerated The anticonvulsants of second generation count between their advantages with a smaller incidence of secondary effects. However, we are considering of relatively new drugs, mainly for its use to the margin of epilepsy, as it is the case of the neuropathic pain. For this reason it is necessary a study and more complete pursuit of its possible secondary effects. We presented 2 cases of sexual dysfunction in a man and a woman in relation to the administration of gabapentin for control of the pain of central origin. The increase of the serotonin concentration could be the cause of the sexual alterations related to the treatment with GBP to the doses used in our patients, superior to 1,800 mg/day. This effect is doses dependent, and the treatment consists of diminishing or fitting the dose to maximize the time interval between the previous taking and to the sexual act.

Keywords : Sexual dysfunction; gabapentin; neuropathic pain.

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