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Revista de la Sociedad Española del Dolor

versão impressa ISSN 1134-8046


LOPEZ-MILLAN, J. M  e  SANCHEZ-BLANCO, C. Current use of ketamine for the treatment of acute and chrnic pain. Rev. Soc. Esp. Dolor [online]. 2007, vol.14, n.1, pp.45-65. ISSN 1134-8046.

Ketamine is an old drug, with low utilization as an anesthetic but an increasing indication in the treatment of acute and chronic pain. Its pharmacological properties and mechanism of action as N-methyl-D-aspartic acid (NMDA) receptor antagonist are well known, but in clinical practice it offers uneven results. Commercialized just as soluble ketamine for injection, it has been used in multiple indications, routes of administration, doses and in combination with many other first line analgesic drugs. This heterogeneity may be responsible for the poor results shown in many clinical studies, most of them with limited clinical evidence. An increasing demand for new analgesics and neuromodulators in general to treat pain, bring to us the need to standarize its regular use as well as to develop new ways of utilization for the old ones.

Palavras-chave : ketamine; pain; treatment.

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