Abstract

SUAZO, I. C.; CANTIN, M. G.  and  ZAVANDO, D. A.. Analysis of the density of NMDA R1 receptors in the spinal nucleus of human trigeminal nucleus. Rev. Soc. Esp. Dolor [online]. 2008, vol.15, n.6, pp.371-376. ISSN 1134-8046.

The trigeminal system is in charge of the painful sensibility of most the oral and maxilofaciales territory, in this function take part the NMDA type receptors that are in the spinal nucleus of trigeminal nerve. The spinal nucleus of trigéminal is subdivided in three subnucleuses in rostrocaudal orientation, named oral, to interpólate and caudal subnucleus. Classic the caudal subnucleus has considered trigeminal to be the place of relief of the painful information. Objective. The objective of the present study was the distribution NMDA analyzed of the glutamatergic receptors in the spinal nucleus of trigéminal nerve. Method. In this study were in use 10 human encefalic trunk obtained of corpses, which byline post mortem was of 8,7 horas (devesta 2,75), which were submitted to transverse sections, 120 anatomical controls being obtained dyeings by Mulligan’s tint and 120 plates submitted to inmunohistoquímica by antibodies monoclonales anti-NMDA R1 (SigmaR) in dilution 1:500 in 0,3 % of Tritón X-100 to ph 7,3 0,1 M. Results. The result show te glutamatergic receptors NMDA R1 type existence in the spinal nucleus on human trigeminal system, with a slight predominance in the caudal subnucleus, without finding a statistically significant difference, its due to the important presence of these recipients in the oral and to interpólate subnuclei. Conclusions. The results suggest that all the levéis of the spinal nucleus of trigémino would take part in the painful transmission originated in the oral and maxilofaciales territory.

Keywords : Trigeminal Nucleus Spinal; NR1 NMDA receptor.

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