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Revista de la Sociedad Española del Dolor

versão impressa ISSN 1134-8046


MESA SUAREZ, P. et al. Opioid related neurotoxicity on pediatric population after general anestesia. Rev. Soc. Esp. Dolor [online]. 2016, vol.23, n.4, pp.181-185. ISSN 1134-8046.

Introduction: In the last decade many scietific publications bring out the results of experimental studies about the neurotoxic impact of an anesthetic expossure in animal's brain. It is confirm that when this expossure occurs in a maximum synaptogenesis period of the animal's live a widespread neuroapoptosis befall. From there on all the pediatrics anesthesiologist warried about if this damage could also affect the pediatric population. Nowadays there are several observational studies exploring the neurobehavioral conduct of many children who underwent general anesthesia early in their lives. Objetive: As a results of this we propose to use actual neuronal damage biomarkes, wich have demonstrated association between brain damage and perinatal hypoxia, or cardiac arrest or mild brain injury. When we planned this essay we intend to determine if S100B protein could work as an accute postanesthetic expossure neuronal damage biomarker, and if there would be any relationship between the biomarker elevation and any of the drugs commonly use for anesthesia. Metodology: In order to determinate the S100B protein serum level is, we obtained a blood sample before and after general anaesthesia expousure in 76 paediatric patient undergoing amigdalar hypertropy surgery. Conclusions: Once we analized our results we can coclude that an elevation of the blood levels of S100B protein occurs after anesthesia. We have also found a possitive correlation between the total amount of fentanyl administred and the higher level of this protein concentration at the end of the anesthetic expossure.

Palavras-chave : Neurotoxicity; neuroapoptosis; S100B protein; general anestesia; fentanyl.

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