Abstract

AMEZCUA-HERNANDEZ, V.; GARCIA, J.  and  VALDIVIA, J.. Immediate-release fentanyl as coadyuvant for control the side effects off immunotherapy. Clinical case. Rev. Soc. Esp. Dolor [online]. 2017, vol.24, n.6, pp.309-312. ISSN 1134-8046.  https://dx.doi.org/10.20986/resed.2017.3589/2017.

The scientific advance and the appearance of immunotherapy in oncology, requires to know both its results in the form of survival, and the toxicity that this contributes.

Pharmacological stimulation of the immune system can cause distortions in the regulation of the immune system and alter the process of immune tolerance, favoring the appearance of excessive autoimmune reactions against healthy organs.

Autoimmune colitis is an immunorelated event that usually courses with diarrhea. Although the treatment axis is corticoids, it is not always possible to control the adverse effect or the pain that, sometimes, these treatment cause. In our case, the use of fast-acting fentanyl for pain control was able to act as a coadjuvant to the immunosuppressive treatment, slowing the intestinal transit and, consequently, favoring the control of the colitis.

Keywords : Immunotherapy; medical oncology; colitis; autoimmunity; diarrhea; immediate release fentanyl.

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