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Print version ISSN 1134-928X


GARCIA MEANA, Javier Federico. Use of sevoflurane topically on leg ulcers: systematized review. Gerokomos [online]. 2020, vol.31, n.2, pp.119-124.  Epub Oct 05, 2020. ISSN 1134-928X.

Leg ulcers are a global problem daily. The analgesic options for pain control are generally based on pharmacological measures with local and / or systemic action. Sevoflurane is a general inhalation anesthetic, associated with its effects on the central nervous system, its use not being traditional by other routes that are not inhaled. However, today it is known an analgesic action at the central level and at the peripheral level. Actually, the clinical use of this product has led some authors to consider the possibility of new effects of Sevoflurane topically.


To synthesize the available scientific evidences about the use of Sevoflurane topically on leg ulcers.


Systematized review of the scientific literature, following the PRISMA guide. The main bibliographic databases were searched without date or language limits. Also references lists and congress abstracts were searched.


120 references were identified. Finally, 8 of them were selected for qualitative synthesis. In most studies, was found a decrease in pain of 8 to 2 points in the scales used.


The few studies suggest an analgesic effect applied topically, a probable antibacterial effect and a possible healing promoting effect. However, comparative studies of large sample are needed, with a better quality designs.

Keywords : Leg ulcer; Sevoflurane; Systematized review.

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