SciELO - Scientific Electronic Library Online

vol.82 issue2Effect of weather temperature on hospital emergencies in the Region of Murcia, Spain, throughout the 2000-2005 and its yse in epidemiological surveillanceOccupational injury in foreign workers by economic activity and autonomous community (Spain 2005) author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google


Revista Española de Salud Pública

On-line version ISSN 2173-9110Print version ISSN 1135-5727


LANA PEREZ, Alberto et al. Survival analysis in multiple cancer patients in Asturias, Spain, 1975-2004. Rev. Esp. Salud Publica [online]. 2008, vol.82, n.2, pp.167-177. ISSN 2173-9110.

Background. Almost one in ten survivors of cancer suffers a second primary. Some studies try to clarify the causes, but there are few that study the time variable. Our research aim was to describe this variable in multiple cancer (MC) patients and to detect others associated with time without MC and survival. Methods. We performed a descriptive study, and the Kaplan Meyer method and Cox Regression were used to study the patients with MC included in the tumour registry of the reference hospital of Asturias. Results. Time between the first symptom and diagnosis was significantly reduced in the second tumour when compared with the first one (113 to 88 days). Time between the first two tumours (median=2.93 years) and the risk of an earlier second primary was higher in older people (RR=1,03) with: primaries diagnosed in advanced stage (RR=1.55), treated with palliative surgery (RR=2.67) or chemotherapy (RR=1.51); second neoplasm located in the prostate (RR=1.67). 60.9% survived at least 5 years after the first diagnosis and 19.1% after the second. These probabilities decreased with age (RR=1.04) and advanced stages (RR=2.48). Nevertheless, locations with good prognosis (prostate, breast or skin) and almost any treatment with surgery or radiotherapy increase survival. Conclusion. Physicians should be alert to new cancer symptoms in patients with previous neoplasms during the follow-up period to improve early MC diagnosis. Survival in MC patients is acceptable, and it largely depends on the location and stage of the cancer involved, but also upon the strategy of treatment.

Keywords : Neoplasms; Second Primary; Survival Analysis; Proportional Hazards Models; Time factors; Prognosis; Prevention and control.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License