Abstract

DEL NERO-VIERA, Guillermo. Resorption as an inflammatory process: An approach to the pathogenesis of dental and periodontal resorption. RCOE [online]. 2005, vol.10, n.5-6, pp.545-556. ISSN 1138-123X.

Resorption (inflammation) and repair are considered two phases of a whole: 1) the resorptive, catabolic or destructive phase and 2) the repairing, anabolic or synthesis phase. The similarity of the aggressive agents, intermediating cytokines and the restorative forms allows us think that dental and bone resorptions of local origin are inflammatoryrepairing processes located in mineralised tissues. This unifying concept is justified by the resorption and inflammation pathogenesis. The aggressive agents (the aetiologies), the basics about the origins, development, cell groups and humoral factors that regulate inflammations and resorptions (the pathogenesis) are reviewed based on classical knowledge. Recent findings that explain why and how blast cells (osteoblasts and odontoblasts), through the RANK-RANKL-OPG autocrine-paracrine system are essential in the clastogenesis and the dental and periodontal resorption-repairing processes of local origin are analysed.

Keywords : Resorption; Reabsorption; Absorption; Inflammation; Osteitis; Periodontitis; Dentinitis; Cementitis; Amelitis; Clasts; Clastogenesis RANK- RANKL-OPG system.

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