Abstract

RODRIGO-GOMEZ, D.; OTEO-CALATAYUD, A.; ALONSO-ROSADO, A.  and  BASCONES-MARTINEZ, A.. The role of genetics in the development and progression of periodontitis: II: Polymorphism associated to periodontal disease. Avances en Periodoncia [online]. 2008, vol.20, n.2, pp.121-130. ISSN 2340-3209.

Periodontitis is a multifactorial disease in which the interaction of periodontal pathogens with the host immune defense machanism characterizes an inflamatory reaction that affects the attachment apparatus of the tooth. Multifactorial diseases normally involve complex genetic-enviromental interactions. The type of genetic variations described in these diseases are defined as polymorphisms. Different polymorphysm have been observed and normally the phenotypic consequences are limited. In the first part of this review the evidence of association between Periodontitis and Genetics is analyzed. In the second part a special focus will be dedicated to research on polymorphysm and the clinical projection related to Periodontitis.

Keywords : Periodontitis; susceptibility; genetic; polymorphism.

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