Abstract

GONZALEZ JIMENEZ, Emilio  and  ALVAREZ FERRE, Judit. Statins: Characteristics and Effects on lipid control in obese children and adolescents. Rev Clin Med Fam [online]. 2011, vol.4, n.1, pp.69-75. ISSN 2386-8201.

Obesity in children and adolescents is an emerging public health problem, with nutritional and metabolic disorder being most prevalent in developed countries. Parallel to this increase in obesity, dyslipidemia is occurring at increasingly early ages. The last decade has seen advances in novel treatments for these lipid abnormalities, mainly due to the introduction of statin therapy. Its utility and effectiveness amply demonstrated in adults appears to be equally applicable in the treatment of hypercholesterolemia in childhood. Currently there are six statins used in children. Their activity in children and adolescents has been studied in clinical trials, which determined their efficacy and safety to reduce both total cholesterol and low density lipoprotein cholesterol (LDL-c) levels. The aim of this study was to provide an update on the characteristics of these statins and their effects on clinical improvement of blood lipid levels in overweight and in obese children and adolescents.

Keywords : Obesity; Child; Statins; Hyperlipidemias; Atherosclerosis.

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