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Revista Clínica de Medicina de Familia

On-line version ISSN 2386-8201Print version ISSN 1699-695X


IGUALADA QUINTANILLA, Jesús; ROMERO CANDEL, Gregorio  and  TEJADA CIFUENTES, Francisco. Metotrexato: toxicidad pulmonar, hepática y hematológica. Rev Clin Med Fam [online]. 2016, vol.9, n.3, pp.159-166. ISSN 2386-8201.

Methotrexate has been widely used for many years in the treatment of a variety of diseases. Low-dose oral methotrexate therapy has gained wide acceptance for its use in rheumatoid arthritis because of its efficacy and tolerability. The toxicity of methotrexate is the main reason for cessation of treatment. Gastrointestinal complications are the most common adverse effects of low-dose oral methotrexate therapy, followed by stomatitis, hepatotoxicity, skin rash, hair loss, pulmonary and haematological toxicity, although pancytopenia is a rare adverse effect of low-dose oral methotrexate therapy. The most important risk factor for methotrexate toxicity is impaired renal function.

Keywords : Methotrexate; Drug-Related Side Effects and Adverse Reactions; Arthritis, Rheumatoid.

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