Abstract

MINARDI, EP. Dapsone as a therapeutic option in the treatment of acne fulminans by isotretinoin. Rev. OFIL·ILAPHAR [online]. 2022, vol.32, n.1, pp.103-104.  Epub Nov 21, 2022. ISSN 1699-714X.  https://dx.doi.org/10.4321/s1699-714x20220001000020.

Acne fulminans is a rare condition characterized by an abrupt onset of nodular and inflammatory lesions on the chest, back, neck and shoulders that rapidly progress to necrotic ulcers with purulent discharge, blood crusts and hypertrophic scars and it may or may not be associated with systemic symptoms. It affects mainly young male patients and the etiopathogenesis is not completely elucidated and immunological, genetic, infectious or hormonal mechanisms have been proposed. There are also a few acne fulminans's clinical cases related to the use of oral isotretinoin probably due to the fragility of the pilosebaceous epithelium induced by this drug, that exacerbate hypersensitivity reactions (type III and IV) after a extensive contact with P. acnes. However, the limited evidence-based information and the lack of clear guidelines on its etiology, classification and treatment complicate the clinical management of the disease, especially when it's induced by isotretinoin. Here is described the case of a young male patient with isotretinoin-induced acne fulminans without systemic symptoms, which was treated with dapsone.

Keywords : Acne fulminans; isotretinoin; dapsone.

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