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Revista de Bioética y Derecho

On-line version ISSN 1886-5887


REBUELTO, Marcela. A valuable reference for the responsible use of animals in scientific research: "International Guiding Principles for Biomedical Research Involving Animals CIOMS-ICLAS". Rev. Bioética y Derecho [online]. 2022, n.55, pp.55-74.  Epub Jan 20, 2023. ISSN 1886-5887.

The use of animals in scientific and educational activities is a subject of debate in society, and at present, these activities are evaluated in their ethical aspect before starting. The purpose of this article was to analyse the International Guiding Principles for Biomedical Research Involving Animals, developed by the Council for International Organizations of Medical Sciences and the International Council for Laboratory Animal Science, on the criteria set as necessary to determine the responsible use of animals, aiming to harmonize regulations. The document takes the former Russell and Burch's statement of the Three Rs (replacement, reduction, refinement), and adds new requirements. Thus, justification, scientific worth of the studies, ways of refinement as humane endpoints, animal welfare, harm-benefit analysis and traits as responsibility, respect and scientific integrity arise as necessary conditions; ethical concerns of society are also considered. Institutions play a major rol in the proficiency and supervision of scientists, and in developing a culture of care. This document provides clear guidelines and constitutes a valuable reference when directives on the protection of animals used in scientific activities are lacking.

Keywords : Animal ethics; biomedical research with animals; responsible research; The Three Rs, ethical principles.

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