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Revista Andaluza de Medicina del Deporte

On-line version ISSN 2172-5063Print version ISSN 1888-7546


TONELLO, L. et al. Aerobic training and lipid profile of hypothyroid rats. Rev Andal Med Deporte [online]. 2013, vol.6, n.2, pp.47-51. ISSN 2172-5063.

Objective. The objective of this study was to investigate the effects of 17 weeks of swimming exercise on the lipid profile of hypothyroid rats. Method. 24 male Wistar rats were divided into four groups: controls submitted to aerobic training (CT); hypothyroid submitted to aerobic training (HT); sedentary controls (SC) and sedentary hypothyroid (SH). HT and SH were induced to hypothyroidism by administering 1 mg of propylthiouracil, while CT and SC animals received distilled water. The animals had unrestricted access to ration and water. Swimming took place five times per week, 60 minutes per session, with overload corresponding to 3% of body weight. At the end of the experiment total cholesterol (C), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), very low-density lipoprotein (VLDL-C), triglycerides and thyroid stimulating hormone (TSH) levels were measured. Results. The main finding of the study was the lower values (p < 0.05) obtained for two variables in the HT group (C = 74.6 ± 8.7 mg/dl and LDL = 43.7 ± 6.5 mg/dl) compared to the SH group (C = 91.3 ± 6.8 mg/dl and LDL-C = 55.6 ± 2.0 mg/dl). Conclusion. It was concluded that swimming exercises can minimize the increase in C and LDL-C blood levels in hypothyroid rats.

Keywords : Hypothyroidism; Exercise; Lipid metabolism; Lipoproteins.

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