Abstract

CAETANO JUNIOR, P.C. et al. Effects of administration of human recombinant erythropoietin on physical performance: study review. Rev Andal Med Deporte [online]. 2014, vol.7, n.4, pp.170-177. ISSN 2172-5063.  https://dx.doi.org/10.1016/j.ramd.2014.03.001.

Objective: Discuss the influence of rHuEPO on physical performance, as well as the adverse effects of this practice, exposing results from experimental and clinical studies. Methods: Were selected articles published in the basis, PubMed and SciELO databases, in the period 1985-2013, using the following keywords eritropoetina/erythropoietin, desempenho atlético/athletic performance, resistência física/physical endurance, efeitos adversos/adverse effects e doping nos esportes/doping in sports. Results: All articles (n = 10) related to the influence of treatment with rHuEPO on sports performance, found improvement in the variables of maximal oxygen uptake (VO_2max) and time to exhaustion in humans, using different protocols dosages between 50 to 60 IU/kg during the first weeks with reduced throughout treatment. Among the most common adverse effects are the thrombovascular accidents, iron deficiency and hypertension. Conclusion: Treatment with rHuEPO doses and at different periods, can enhance physical performance in humans, because of the different generated effects, including increased O₂ transport, reduction of blood lactate concentrations, increased concentrations of free fatty acids in the blood and muscle glycogen.

Keywords : Erythropoietin; Athletic performance; Physical endurance; Adverse effects; Doping in sports.

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