Resumo

GINER, M. et al. What are microRNAs?: potential biomarkers and therapeutic targets in osteoporosis. Rev Osteoporos Metab Miner [online]. 2016, vol.8, n.1, pp.40-44. ISSN 2173-2345.

Micro-RNAs (miRs) are small non-coding RNA molecules that regulate gene expression at post-transcriptional level. Generally, they act on gene expression by silencing or degrading mRNAs, and are involved in regulating various biological processes, such as cell differentiation, proliferation, apoptosis and in embryonic and tissue development. They are currently a major focus of interest in the study of various diseases such as cancer or type 2 diabetes mellitus. At level of bone metabolism, various miRs are emerging that are involved in their regulation, opening an important research field to identify new biomarkers for diagnosis of osteoporosis and its development, and to design new drug therapies.

Palavras-chave : epigenetics; micro-RNA; biomarkers and osteoporosis.

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