SciELO - Scientific Electronic Library Online

vol.9 issue1Effects of the catalase antioxidant enzyme in vascular calcification and bone demineralizationIdentification of genetic variants associated with bone mineral density (BMD) in the FLJ42280 gene author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google


Revista de Osteoporosis y Metabolismo Mineral

On-line version ISSN 2173-2345Print version ISSN 1889-836X


GINER, M et al. Influence of obesity on microarchitecture and biomechanical properties in patients with hip fracture. Rev Osteoporos Metab Miner [online]. 2017, vol.9, n.1, pp.20-27. ISSN 2173-2345.


Obesity and osteoporosis (OP) are two very prevalent diseases in our society today. The effect of obesity on bone quality is currently a subject under discussion.


To assess the effect of body weight on the microstructure and biomechanical properties of trabecular bone biopsies from the proximal end of the femur in patients with hip fracture fragility.

Material and Methods:

Cross-sectional study of 16 patients with hip fracture. The 2 groups are divided according to their BMI: (A) normal weight individuals and (B) those with obesity. We collected biopsies of cancellous bone from the femoral head and assessed biochemical determinations (PTH, 25 (OH) vitamin D and IGF-1), bone remodeling markers (PINP, CTX), bone mass (BMD neck and total hip), bone microstructure and biomechanical study (µCt). Statistical analysis: Student's t test (SPSS 22.0) significance p<0.05.


All patients had hip BMD in osteoporotic range. The obese group had higher levels of PTH and lower IGF-1, vitamin D and PINP. We found no differences in the parameters related to bone metabolism. The obese group showed better indices reaching microstructural significance: increased bone volume (BV/TV: 36.6±12.7 vs 19.4±11.4%, BS/TV: 5.5±1.1 vs 3.9±1.3%), higher trabecular number (Tb.N: 1.6±0.4 vs 1,01±0,4), greater trabecular width (Tb.Th: 0.22±0.003 vs 0.17±0.05) and lower trabecular separation (Tb.Sp: 0.51±0.12 vs 0.66±0.16). Biomechanical parameters confirm greater strength of trabecular bone in obese patients.


Obesity may be a protective factor of bone quality in the femoral region and has less effect on bone mineral density.

Keywords : osteoporosis; obesity; microstructure trabecular bone; biomechanics; bone mineral density; bone turnover markers.

        · abstract in Spanish     · text in English | Spanish     · English ( pdf ) | Spanish ( pdf )