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Revista de Osteoporosis y Metabolismo Mineral

versión On-line ISSN 2173-2345versión impresa ISSN 1889-836X


VAZQUEZ GAMEZ, MA et al. Changes in bone mass in a child population with type 1 diabetes mellitus. Longitudinal study. Rev Osteoporos Metab Miner [online]. 2022, vol.14, n.2, pp.82-87.  Epub 12-Sep-2022. ISSN 2173-2345.


To evaluate, over a 79.2-month follow-up period, the behavior of bone mineral density (BMD) determined by Computerized Axial Densitometry (DXA), volumetric bone mineral density (BMDvol) and its relationship with anthropometric data, together with the parameters related to bone metabolism (calcium, phosphorus, alkaline phosphatase, parathormone (PTH) and vitamin D (25-OH-D3)) in a child population with Type 1 Diabetes Mellitus (DM1) without microvascular complications and a control group of reference with similar characteristics.

Patients and methods:

Transversal study in which 2,283 women aged 60 to 94 years were selected. We calculated the risk of major osteoporotic and femoral neck fractures with the Ecuadorian FRAX model (version 4.1), and calculated the proportion of individuals eligible for treatment and bone mineral density assessment applying age-specific thresholds of 60 to 94 years and a fixed threshold from 75 years.


It was observed that, at baseline, bone mass was similar in diabetics and controls. After follow-up, the BMD of the diabetic children was much lower than that expected in the non-diabetic child population. Weight, height, and Body Mass Index (BMI) followed the same pattern as BMD. The values of calcium, phosphorus, alkaline phosphatase, PTH and vitamin D, although within the normal range, were lower than in the controls. Alkaline phosphatase did not increase in the pubertal period.


The present study demonstrates that children and adolescents with a recent diagnosis of DM1 have a normal BMD. However, over time, and especially during adolescence, they show less bone mass gain and changes in bone turnover parameters.

Palabras clave : type 1 diabetes mellitus; childhood; bone mineral density; bone turnover; longitudinal study.

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