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Revista de Osteoporosis y Metabolismo Mineral

versión On-line ISSN 2173-2345versión impresa ISSN 1889-836X


FLOREZ, H et al. Usefulness of the trabecular bone score in adult subjects with osteogenesis imperfecta. Rev Osteoporos Metab Miner [online]. 2022, vol.14, n.4, pp.125-130.  Epub 27-Mar-2023. ISSN 2173-2345.


To analyze the usefulness of the trabecular bone score (TBS) in adults with osteogenesis imperfecta (OI) and its relationship with clinical, anthropometric and densitometric variables, especially with the presence of fractures and the severity of the disease.

Material and methods:

Cross-sectional study conducted in 31 adult patients with OI (age 40.5±15.2 years, 68% women, 87% type I). The clinical characteristics of the patients (fractures, type of OI, BMI and treatment), bone mineral density (BMD) (using DXA), assessing the presence of densitometric osteoporosis, and TBS values (TBS iNsight), estimating the presence of degraded microarchitecture (values <1.230). The results were compared between the different OI types (I and III-IV) and with those of a control group of healthy subjects.


Most of the patients (29/31, 94%) had a history of fractures and 29% received antiosteoporotic treatment. 61% had densitometric osteoporosis and 19% had degraded microarchitecture. No differences were observed in the TBS values according to OI severity (OI type I vs. III-IV: 1,297 vs. 1,339, p=n.s.); no patient with OI type III-IV had TBS <1230. TBS values were related to age (r=-0.6, p<0.01), lumbar BMD (r=0.4, p=0.03) and BMI (r=-0.5 , p=0.01). Patients with OI had lower values of TBS and BMD than the control group in all locations analyzed.


TBS is not very sensitive in assessing bone quality in OI, since none of the patients with severe OI had a degraded microarchitecture and this was only observed in 19% of patients with OI despite presenting a high prevalence of fractures.

Palabras clave : osteogenesis imperfecta; trabecular bone score; TBS.

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