Resumen

GARCIA-FONTANA, Beatriz  y  RIANCHO, José A. Dialogues between basic and clinical researchers: hypophosphatasia. Rev Osteoporos Metab Miner [online]. 2024, vol.16, n.2, pp.56-60.  Epub 17-Feb-2025. ISSN 2173-2345.  https://dx.doi.org/10.20960/revosteoporosmetabminer.00046.

Most serum alkaline phosphatase (ALP) (> 90 %) originates from the liver and bone. Normally, the contribution from other tissues, such as the intestine or kidney, is much smaller, although the placenta is an important source during pregnancy. Elevated ALP levels are usually indicative of liver or bone disease.

The analysis of other liver enzymes, particularly GGT—which is elevated in liver damage and normal in bone diseases—usually clarifies the origin. When in doubt, the bone isoform can be measured, or a profile of all isoenzymes can be conducted.

Palabras clave : Alkaline phosphatase; Biomarker; Hypophosphatasia; ALPL; Genetics.

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