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Revista Española de Nutrición Humana y Dietética

On-line version ISSN 2174-5145Print version ISSN 2173-1292


CABANAS-ALITE, Luis et al. Changes in nutritional status, body composition and associated symptomatology in hospitalized patients undergoing bone marrow transplantation: prospective longitudinal study. Rev Esp Nutr Hum Diet [online]. 2021, vol.25, n.2, pp.154-164.  Epub Jan 17, 2022. ISSN 2174-5145.


Patients undergoing Hematopoietic Stem Cells Transplant or marrow transplantation have several nutritional complications. The objective of the study was to track a description prospectively in hospitalized patients for a transplantation.

Material and Methods

14 patients with an average age of 48.0±9.8 years were recruited.


28.6% were overweight, 14.3% obese and 57.1% were normally weighted, with an evolution between -0.3±0.3kg/m2 (normoweight) to -3.1±0.2kg/m2 (obesity). Variable weight loss of up to 7.3±0.7% was observed in patients with higher Body Mass Index (BMI). Body composition also worsened to hospital discharge, with an evolution of brachial circumference of -1.7±0.4cm in allogeneic transplantation and -2±4.5cm in autologous transplantation. A 42.9% of men and 28.6% of women were discharged with an Fat Free Mass Index (FFMI) below the recommendations, increasing from admission in men (from 14.3%). A loss of muscle strength is observed, in allogeneic transplantation of -5.0±1.5kg in the case of men, and -3.0±0.5kg in women; -5kg and -4kg, respectively. About adverse effects, there was a high prevalence of vomiting (71.4%), nausea (42.9%) early satiety (57.1%); during hospitalization, highlights early satiety (92.9%), nausea (71.4%), vomiting (71.4%), dysgeusia (57.1%), diarrhoea (50%) anorexia (50%).


Patients admitted to bone marrow transplantation are apparently well nourished, and there is a deterioration during hospitalization; it seems appropriate to implement dietary strategies during hospitalization to optimize intake and prevent malnutrition.

Keywords : Body Composition; Bone Marrow Transplantation; Nutritional Status; Adverse effects.

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