Abstract

COBO SANCHEZ, José Luis et al. Biocompatibility comparative study between online hemodiafiltration and hemodiafiltration with endogenous reinfusion. Enferm Nefrol [online]. 2012, vol.15, n.4, pp.271-276. ISSN 2255-3517.  https://dx.doi.org/10.4321/S2254-28842012000400005.

Aim: To compare biocompatibility between online hemodiafiltration (HDF) and hemodiafiltration with endogenous reinfusion. Methods: Observational comparative study in a population of 15 chronic hemodialysis patients randomly selected among the patients in our unit. We compared changes in hematological profile, CRP level and vital signs, pre and post hemodialysis, after undergoing both hemodiafiltration techniques. Comparing the differences between the parameters studied before and after each hemodialysis technique. Results: Platelet levels decreased more in the HDF (HDF -1,33 vs HFR -19,73 x10³/mm³, p=0,005). Leukocyte levels decreased in the HDF and increased with HFR (HDF -0,46 vs HFR +0,8 x10³/mm³; p=0,006). Regarding the leukocyte formula had mixed results: segmented HDF -1,7 vs HFR +5,4%, p<0,001; lymphocytes HDF +1,96 vs HFR -3,62%, p<0,001. With the HFR decreased CRP levels less (HDF -0,05 vs HFR -0,001 mg/dl; p= NS). Regarding vital signs, systolic blood pressure decreased more in the HFR than HDF (HDF -9,93 vs HFR -10,33 mmHg; p<0,001), conversely that the diastolic blood pressure (HDF -5,2 vs HFR -3 mmHg; p=0,007), and heart rate (HDF -1,46 vs HFR +1,73 lpm; p=NS). Body temperature increased more with the HDF that the HFR (HDF +0,35 vs HFR +0,06 ^oC; p=NS). Conclusions: According to our results the HFR seems more biocompatible than the HDF, probably derived by exogenous reinfusion of HDF.

Keywords : Online hemodiafiltration; Hemodiafiltraton with endogenous reinfusion; Materials testing; Body temperature changes; Leukocyte count.

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