Abstract

DIAZ PLATAS, Lucía et al. Relationship between radiochemical purity of ¹²³i-ioflupane and extracranial image captation (parotid and thyroid). Ars Pharm [online]. 2015, vol.56, n.4, pp.225-230. ISSN 2340-9894.  https://dx.doi.org/10.4321/S2340-98942015000400006.

Aim: The aim of this study is to see the effect of radiochemical purity (PR) of ¹²³I- Ioflupane used for cerebral dopamine transporter SPECT (Single Photon Emission Computed Tomography) on the images and evaluate the possible influence of extravasation during the administration in patient with Parkinson syndrome. Material and methods: A Prospective study was performed in 39 patients. The PR of 123I-Ioflupane was determined by radiochromatography. The regions of interest (ROI) were defined in general area of the brain, parotid and cervical region, obtaining the average counts in each region and activity ratios thyroid / brain (RTC) and parotid / brain (RPC). It was proposed a model of multiple linear regression with quantitative and categorical predictors Results: The model showed that correlation between the PR and the RTC was modified by the presence of extravasation, it was statistically significant (p < 0.001) and predicted the 42.31 % of the variability of the RTC. The correlation between PR and PRC was not modified by any of the variables proposed. The model was statistically significant (p < 0.0176) and 12.3% predicted variability RPC. Conclusions: The predictive variability of the model of RTC is acceptable and explains the negative impact of extravasation. However, the ability to explain the variability of the PRC is low and should not be attributed to variables studied. A low PR and extravasation during the administration of the radiopharmaceutical involves worse quality of image and increased thyroid irradiation.

Keywords : Ioflupane; ¹²³Iodure; Radiocromatography; Radiochemical; Thyroid captation; Thin layer chromatography.

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