Abstract

GARCIA-CORVILLO, M.ª del Pilar. Polymeric Nanoparticles for Drug Delivery to the Central Nervous System Via Nasal Route. Ars Pharm [online]. 2016, vol.57, n.1, pp.27-35. ISSN 2340-9894.  https://dx.doi.org/10.30827/ars.v57i1.4384.

Objectives: The main objective of this study is to analyse the current researches related to polymeric nanoparticles as a system of drug delivery, as well as the studies that show the different ways in which the drugs included in this system and delivered into the central nervous system are apply through intranasal delivery. Methods: The elaboration of this study has required the exhaustive analysis of different scientific articles related to polymeric nanoparticles and drug delivery systems. The National Library of Medicine, Washington, DC (MEDLINE: PlubMed) has been the main source of information from which the scientific articles used to carry out this study have been selected. Results: Many of the drugs employed for the treatment of neurodegenerative diseases are not capable of going through the blood-brain-barrier (BBB) and reach the brain with enough concentration, being unable to apply their therapeutic effect. That is why the idea of developing polymeric nanoparticles to be delivered through nasal delivery come out. Thanks to the use of this system, many researches have shown an improvement in the clinical utility of the drug, reducing the dose and the frequency of dosing as well as the side effects. Conclusions: Despite the improvements in this field that demonstrate an increase in the concentration of drugs, included in the nanoparticles systems, that reaches the brain, it is still necessary to carry out researches in order to solve issues related to the toxicity and the variability in the absorbed dose that these systems present.

Keywords : nanoparticles; polymeric nanoparticles; intranasal delivery; brain targeting.

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