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Ars Pharmaceutica (Internet)

On-line version ISSN 2340-9894


GULATI, Neha; TOMAR, Neha  and  NAGAICH, Upendra. Miconazole Microsponges based topical delivery system for diaper dermatitis. Ars Pharm [online]. 2016, vol.57, n.2, pp.77-87. ISSN 2340-9894.

Aim: The current investigation was aimed to develop and optimize the microsponges of miconazole nitrate for treatment of diaper dermatitis for enhanced therapeutic effect. Material and Methods: Microsponges were developed by emulsion solvent diffusion technique using 23 factorial design. Fabricated microsponges were optimized in order to analyze the effects of independent variables on the encapsulation efficiency, particle size, surface topography and in vitro drug release. The optimized formulation was then incorporated into the gel and evaluated. Results: Particle size of all formulations was found to be uniform and scanning electron microscopy (SEM) indicates spherical shape and porous nature of microsponges. In vitro drug release studies of all formulations revealed the release rate within the range of 67%±0.09 to 80.6%± 0.68 at the end of 12 hours. On its basis, formulation F8 was selected and incorporated into the gel (CF8) which was evaluated for pH, viscosity, spreadability, in vitro drug diffusion studies, in vitro anti fungal studies and stability studies. Conclusion: The formulated microsponge-based gel of miconazole nitrate would be a capable substitute to traditional treatment for reliable and economical cure of diaper dermatitis.

Keywords : Microsponge delivery system; Eudragit RS100; Miconazole Nitrate; Topical Drug Delivery; yeast diaper dermatitis.

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