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Ars Pharmaceutica (Internet)

On-line version ISSN 2340-9894


CHAVEZ-ALCANTARA, Leyly; CABANILLAS-VARGAS, Yesica; RUIZ-REYES, Segundo  and  GUEVARA-VASQUEZ, Ana María. Phytochemical screening and hepatoprotective potential of Niphidium albopunctatissimum Lellinger on alcoholic hepatoxicity induced in albino rats. Ars Pharm [online]. 2020, vol.61, n.3, pp.187-192.  Epub Aug 17, 2020. ISSN 2340-9894.


To identify the phytoconstituents and determine the effect of Niphidium albopunctatissimum Lellinger on alcoholic hepatoxicity induced in albino rats.


Phytochemical screening was performed using the drop Test. For hepatoxicity study, albino rats were randomized into 5 groups of 6 each. Healthy group: without hepatoxicity; Control group: hepatotoxicity; Curative group: hepatotoxicity plus fluid extract of N. albopunctatissimum Lellinger; Standard group: hepatotoxicity plus silymarin; Preventive group: Fluid extract of N. albopunctatissimum Lellinger for one week, then hepatotoxicity. Hepatotoxicity was induced with 56% (w / v) ethanol at doses of 7.6 mL / kg p.c every 12 hours for 7 days. Glutamic pyruvic transaminase (GPT) values were determined at baseline, 7 days after induction and 14 days after. A histopathological study of the livers was performed.


Phytochemical screening revealed the presence of polyphenols, anthocyanidins, saponins, flavonoids and tannins. The preventive and standard groups showed a very significant decrease in serum GPT levels compared to control group (p <0.01), and curative group did so significantly (p <0.05). Histopathological analysis showed in curative group some degenerating hepatocytes, many with normal-looking cytoplasm; the preventive and standard groups presented hepatocytes with normal architecture and some in degeneration, unlike the evident degeneration and necrosis in control group.


Niphidium albopunctatissimum Lellinger may have hepatoprotective potential against alcoholic toxicity induced in albino rats.

Keywords : Phytochemicals; Liver; Plant extracts; Ethanol.

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