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Ars Pharmaceutica (Internet)
versión On-line ISSN 2340-9894
Resumen
DIAZ-BASURTO, Diana Daniela et al. Preclinical evaluation of the anti-inflammatory activity of a gel with tea tree oil. Ars Pharm [online]. 2024, vol.65, n.1, pp.36-44. Epub 23-Ago-2024. ISSN 2340-9894. https://dx.doi.org/10.30827/ars.v65i1.29152.
Objective:
To evaluate the anti-inflammatory activity of a semi-solid Tea Tree Oil (TTO) form at 2 % and 2,5% concentrations for treating periodontal disease.
Method:
A preclinical test in a sample of 30 mice with ear edema induced by croton oil was divided into two groups to compare treatment with Indomethacin and Diclofenac.
Results:
TTO at 2,5 % concentration showed a higher inhibition activity of inflammation (54,74 %) than TTO at 2 % (51,21 %). Statistical analysis showed no significative differences between treatment combinations (p>0,05).
Conclusions:
The tea tree oil in semi-solid form, applied in 2 - 2,5 % concentration in this preclinical study, showed consistent anti-inflammatory activity.
Palabras clave : Anti-inflammatory agents; periodontal disease; phytotherapy; tea tree oil; preclinical drug evaluation.
