Resumo

SANCHEZ-MUNIZ, Francisco J; CULEBRAS, Jesús M  e  VICENTE-VACAS, Luis. JONNPR and the research carried out on the way to the Nobel Prize 2019. A personal view on the molecules and the molecular aspects and underlying control mechanisms related to hypoxia and cancer. JONNPR [online]. 2020, vol.5, n.3, pp.246-258.  Epub 28-Set-2020. ISSN 2529-850X.  https://dx.doi.org/10.19230/jonnpr.3452.

This special article discusses the mechanisms and central aspects related to three molecules: erythropoietin, hypoxia-induced factor (HIF) and von Hippel-Lindau protein (pVHL) that have led after multiple investigations to win the Nobel Prize in Physiology and Medicine 2019 to scientists William G. Kaelin, Gregg L. Semenza and Peter J. Ratcliffe. The molecular mechanisms taking place in a situation of normoxia, hypoxia and pseudohypoxia are indicated. The article ends by pointing out the pharmacological perspectives that the research of these scientists has opened in the field of cancer and many degenerative diseases.

Palavras-chave : Nobel Prize; Hypoxia; Normoxia; HIF; VHL; Pharmacological perspectives.

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