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Journal of Negative and No Positive Results

On-line version ISSN 2529-850X


RODRIGUEZ PENA, Yeidys et al. Urine excretion of urates in obese children and adolescents affected by Metabolic Syndrome. JONNPR [online]. 2020, vol.5, n.3, pp.307-328.  Epub Sep 28, 2020. ISSN 2529-850X.


Disorders of the metabolism of nitrogen bases eventually translating into an increased urine excretionof urates might be present in the Metabolic Syndrome (MS) associated with obesity


To describe the behavior of urates urine excretion in obese children and adolescents diagnosed with MS

Study design

Analytical, cross-sectional.

Study serie

Fifty-two obese children and adolescents assisted at the Outpatient Clinic of the Endocrinology Service, “Juan Manuel Márquez” Pediatric Teaching Hospital (Havana city, Cuba).

Material and method

Presence of MS in the studied children and adolescents (Boys: 52.0%; Average age: 11.4 ± 3.9 years) was established from the concurrence of augmented abdominal circumference (CA) plus 1 (or more) of any of the followingrisk factors (RF): blood hypertension, Diabetes mellitus, and dyslipidemias. Urates/creatinine (mg/mg) index in urine morning samples was obtained in all cases. Urates urine excretion (mg. 24 hours-1) was estimated from the calculated urates/creatinine index after adjusting for sex andheight. 24 hours uricosuria values thus estimated, and hyperuricosuria states (24 hours uricosuria > cutoff point for age), were distributedaccording with MS presence.


Thirty-four-point-six percent of the children presented with one (or more) manifestations of MS. Frequency of hyperuricosuria for the entire serie was 55.8%. Children with MS exhibited higher uricosuria values (∆ = +56.8 mg. 24 hours-1; p > 0.05) and a greater frequencyof hyperuricosuria (∆ = +25.2%; p > 0.05). Frequency of hyperuricemia was just 3.8%.


MS might be associated with an increasedurates excretion.

Keywords : Metabolic Syndrome; 24 hours uricosuria; Hyperuricosuria; Urates/Creatinine index.

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