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Journal of Negative and No Positive Results
On-line version ISSN 2529-850X
Abstract
GARCIA-ARAGONES, Laura et al. Meningeal carcinomatosis as the initial manifestation of lymphoma. JONNPR [online]. 2022, vol.7, n.4, pp.322-327. Epub Sep 25, 2023. ISSN 2529-850X. https://dx.doi.org/10.19230/jonnpr.4820.
Introduction:
Leptomeningeal carcinomatosis (LC) is diagnosed in 4-15% of cancer patients, and most cases (70%) are in the advanced phase of the disease. In only 5-10% of patients with LC, it is the initial manifestation of cancer.
Case report:
We present a case of a 46-year-old man with leptomeningeal carcinomatosis as the first manifestation of type B high-grade lymphoma. Cerebrospinal fluid (CSF) showed pleocytosis with a predominance of mononuclear cells, hyperproteinorrhachia, and glucose consumption. CSF cytology was negative for malignant cells in two samples. Magnetic resonance imaging and CSF flow cytometry gave the diagnosis.
Discussion:
LC is a diagnostic challenge. Differential diagnosis arises with infectious processes (tuberculosis) and autoimmune diseases. In cerebrospinal fluid, flow cytometry (FCM) has a higher sensitivity than cytology for the diagnosis of LC.
Keywords : Leptomeningeal carcinomatosis; type B lymphoma; flow cytometry; CSF cytology.
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