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Nutrición Hospitalaria

On-line version ISSN 1699-5198Print version ISSN 0212-1611

Nutr. Hosp. vol.32 n.2 Madrid Aug. 2015

https://dx.doi.org/10.3305/nh.2015.32.2.9204 

ORIGINAL / Cáncer

 

Relationship between zincemia, superoxide dismutase activity and marker of oxidative stress in women with breast cancer

Relación entre zincemia, actividad de la enzima superóxido dismutasa y marcador de estrés oxidativo en mujeres con cáncer de mama

 

 

Camila Guedes Borges de Araújo1, Aldenora Oliveira do Nascimento Holanda1, Cinthya Vivianne de Souza Rocha1, Ayla Patricia Soares do Nascimento1, Camila Maria Simplício Revoredo1, Benedito Borges da Silva2, Nadir do Nascimento Nogueira1 and Dilina do Nascimento Marreiro1

1Department of Nutrition, Federal University of Piauí, Campus Ministro Petrônio Portela, Ininga, Teresina (Piauí).
2Department of Mastology and Gynecology, Federal University of Piauí, Campus Ministro Petrônio Portela, Ininga, Teresina, Piauí (Brazil).

 

 


ABSTRACT

Introduction: studies show changes in zinc metabolism in women with breast cancer. This mineral has antioxidant action, and disorders in its biochemical parameters are related to poor prognosis of the disease and increase in the carcinogenic process.
Objective: this study evaluated the activity of enzyme superoxide dismutase and biochemical parameters related to zinc, and investigated the existence of correlation between these variables and the marker of oxidative stress in these patients.
Methods: this was a case-control study with 66 women aged between 20 and 50 years old, distributed into: case group (women with breast cancer, n = 34) and control group (healthy women, n = 32). Zinc intake was analyzed by three-day food diary, using Nutwin software, version 1.5. Plasma and erythrocyte zinc concentrations were determined by flame atomic absorption spectrophotometry method (λ = 213.9). Superoxide dismutase activity was assessed by Griess colorimetric method, and plasma thiobarbituric acid reactive substances (TBARS) were analyzed.
Results and discussion: mean levels of zinc intake, superoxide dismutase and TBARS were higher than recommended for the study participants with statistical difference for enzyme superoxide dismutase (p<0.05). Mean plasma and erythrocyte concentrations of zinc were reduced in both groups (p>0.05).
Conclusions: therefore, it can be assumed that zinc intake in women with breast cancer does not impact plasma and erythrocyte concentrations of this mineral. High superoxide dismutase activity in women with breast cancer may be due to a compensatory mechanism of regulation via oxidative stress found in this disease.

Key words: Breast neoplasms. Zinc. Superoxide dismutase. Oxidative stress.


RESUMEN

Introduccion: diversos estudios muestran alteraciones en el metabolismo del zinc en mujeres con cancer de mama. Este mineral posee accion antioxidante, y los disturbios en sus parametros bioquimicos estan relacionados con peor pronostico de la enfermedad y agravamiento del proceso carcinogenico.
Objetivos: este estudio evaluo la actividad de la enzima superoxido dismutasa y los parametros bioquimicos relativos al zinc e investigo la existencia de correlacion entre esas variables y el marcador del estres oxidativo en estas pacientes.
Metodos: este fue un estudio caso-control con 66 mujeres, con edad ente 20 y 50 anos, distribuidas en: grupo caso (mujeres con cancer de mama, n = 34) y grupo control (mujeres saludables, n = 32). La ingestion del zinc fue realizada por medio del registro alimentario de tres dias, utilizando el programa Nutwin version 1.5. Las concentraciones de zinc plasmatico y eritrocitario fueron determinadas segun el metodo de espectrofotometria de absorcion atomica de llama (λ = 213,9). La actividad de la superoxido dismutasa fue evaluada por el metodo colorimetrico de Griess y fueron analizadas sustancias reactivas al acido tiobarbiturico (TBARS).
Resultados y discusion: los valores medios de la ingestion de zinc, superoxido dismutasa y TARBS eran superiores a los recomendados para las participantes del estudio, con una diferencia estadistica para la enzima superoxido dismutasa (p>0,05). La media de las concentraciones plasmatica y eritrocitaria de zinc fueron reducidos en ambos grupos (p>0.05).
Conclusiones: por lo tanto, se puede suponer que la ingesta de zinc en mujeres con cancer de mama no influye en las concentraciones plasmaticas y eritrocitarias de ese mineral. La elevada actividad de la superoxido dismutasa en las mujeres con cancer de mama puede ser debida a un mecanismo de regulación compensatorio mediante el estrés oxidativo presente en esa enfermedad.

Palabras clave: Neoplasias de la mama. Zinc. Superóxido dismutasa. Estrés oxidativo.


 

 

http://scielo.isciii.es/pdf/nh/v32n2/40originalcancer02.pdf

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