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Nutrición Hospitalaria

On-line version ISSN 1699-5198Print version ISSN 0212-1611

Nutr. Hosp. vol.32 n.4 Madrid Oct. 2015

https://dx.doi.org/10.3305/nh.2015.32.4.9464 

ORIGINAL / Pediatría

 

Behavior of adipokines after a year follow-up in the Obesity Outpatient Clinic for Children and Adolescents

Comportamiento de las adipocinas después de un año de seguimiento en el ambulatorio de obesidad de la niñez y la adolescencia

 

 

Fernanda Miraglia1, Carla Rosane de Moraes Silveira2, Mariur Gomes Beghetto3, Fernanda dos Santos Oliveira4 and Elza Daniel de Mello5

1Nutritionist, Master in Medical Sciences: Nephrology (FAMED/UFRGS), PhD in Children and Adolescents Health, Professor in the Nutrition Course and Graduation Course in Health and Human Development of the Centro Universitário La Salle, Canoas, RS.
2Nutritionist, Master in Children and Adolescents Health, Clinical Nutritionist at the Hospital de Clínicas de Porto Alegre, Nutrology Service, Porto Alegre, RS.
3Doctor in Epidemiology, Department of Professional Help and Guidance (DAOP) of the Nursing School of the Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS.
4PhD in Children and Adolescents Health, UFRGS. Reviewer for the Journal of Pediatric Surgery (Print), Porto Alegre, RS.
5PhD in Pediatrics, Nutrology Service of the HCPA and Pediatrics Department (FAMED/UFRGS), Porto Alegre, RS, Brazil.

 

 


ABSTRACT

Objective: demonstrate adipokines progression, along 12 months, in obese children and adolescents who attend the Obesity Outpatient Clinic for Children and Adolescents of the HCPA.
Methods: children and adolescents in medical treatment for obesity were followed for 12 months, assessing anthropometry, blood pressure, waist circumference, lipid profile, fasting blood sugar and insulin, inter leukine- 6, tumor necrosis factor alpha, and adiponectin in two points in time: at inclusion and after 12 months follow-up in the Obesity Outpatient Clinic for Children and Adolescents.
Results: 27 children and adolescents were assessed with median age of 10.3 years. The mean BMI z-scores lowered during this period (p < 0.01), HDL-c increased in the period (p = 0.025). The medians of adipokines did not vary during the period: IL-6 (p = 0.470), TNF-α (p = 0.753) and adiponectin (p = 0.943). There was no correlation of IL-6 and TNF-α with central and global obesity along the 12-months follow-up. Adiponectin increased in 45% of the sample, the increase being more pronounced in females.
Conclusion: children and adolescents in medical treatment for obesity, after one-year follow-up, did not improve their adiponectin profile.

Key words: Children. Obesity. Adolescents. Adiponectin. Inflammation.


RESUMEN

Objetivo: demostrar la evolución de las adipocinas a lo largo de 12 meses en niños obesos usuarios del Ambulatorio de Obesidad Infantojuvenil.
Métodología: se hizo el seguimiento de niños y adolescentes en tratamiento clínico para obesidad a lo largo de 12 meses. Se los evaluó en lo tocante a antropometría, presión arterial, circunferencia de cintura, perfil lipídico, glicemia e insulina en ayuno, interleucina 6, factor de necrosis tumoral alfa y adiponectina en dos instancias: inclusión y después de 12 meses de seguimiento en el Ambulatorio de Obesidad Infantojuvenil.
Resultados: se evaluaron 27 niños y adolescentes con una media de edad de 10,3 años. Los valores promedio de la puntuación-z del IMC bajaron en el periodo (p < 0,01), el HDL-c aumentó sus niveles en este periodo (p = 0,025). Las medianas de las adipocinas no variaron a lo largo del periodo: IL-6 (p = 0,470), TNF-α (p = 0,753) y adiponectina (p = 0,943). No hubo correlación entre la IL-6 y el TNF-α con obesidad central y global a lo largo de los 12 meses de seguimiento. El 45% de la muestra aumentó sus valores de adiponectina, siendo mayor este aumento en el sexo femenino.
Conclusión: los niños y adolescentes en tratamiento clínico para obesidad tras un año de seguimiento no mejoraron su perfil de adipocinas.

Palabras clave: Niños. Obesidad. Adolescentes. Adipocinas. Inflamación.


 

 

http://scielo.isciii.es/pdf/nh/v32n4/19originalpediatria04.pdf

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