SciELO - Scientific Electronic Library Online

vol.30 issue1Biopsychosocial functioning among cirrhotic patients in various stages of transplant process in comparison to liver transplant recipientsSelf-efficacy, Catastrophizing, Fear of Movement and health out-comes in Fibromyalgia author indexsubject indexarticles search
Home Pagealphabetic serial listing  


Services on Demand




Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google


Anales de Psicología

On-line version ISSN 1695-2294Print version ISSN 0212-9728

Anal. Psicol. vol.30 n.1 Murcia Jan. 2014 


Effectiveness of psychological interventions intended to promote adjustment of children with cancer and their parents: an overview

Eficacia de intervenciones psicológicas dirigidas a promover el ajuste de niños con cáncer y de sus padres: una revisión



Amanda Muglia-Wechsler1, Carmen Bragado-Álvarez1, and María J. Hernández-Lloreda2

1 Universidad Complutense de Madrid, Departamento de Personalidad, Evaluación y Tratamiento Psicológico I (Psicología Clínica)
2 Universidad Complutense de Madrid, Departamento de Metodología de las Ciencias del Comportamiento





This article aims at providing a general overview of psychological interventions intended to promote psychological adjustment of children with cancer and their parents. To achieve this goal, we reviewed published articles between 1998-2010, using a combination of the following key words: psychosocial intervention, psychotherapy, trial, treatment, adjustment, wellbeing, adaptation, cancer, childhood cancer, pediatric cancer, anxiety and depression in the electronic databases: Psycinfo, Medline, Scielo, Lilacs, Psicodoc and Psyarticles. Fourteen articles were found and analyses show that most interventions had some efficacy in the psychological adjustment of children and their parents; nevertheless, there is a limited number of treatments that can in fact be considered effective. The convenience of psychological interventions is discussed and how they must comprehend strengths and the promotion of psychological health and should not be based solely on deficits and psychopathological models. Possibly, this reorientation will help fostering significant clinic changes regarding the stress associated to cancer and its treatment.

Key words: Psychological adjustment, psychological interventions, childhood cancer, overview.


Esta revisión tiene como objetivo ofrecer un panorama general sobre la eficacia de las intervenciones psicológicas destinadas a promover el ajuste psicológico de niños aquejados de cáncer y de sus padres. Con este fin se revisaron los artículos publicados entre 1998-2010, empleando las siguientes palabras clave: intervención psicosocial, psicoterapia, ensayo, tratamiento, ajuste, bienestar, adaptación, cáncer, cáncer infantil, cáncer pediátrico, ansiedad y depresión (combinándolas entre sí) en las siguientes bases de datos: Psycinfo, Medline, Scielo, Lilacs, Psicodoc y Psyarticles. Se localizaron un total de catorce artículos, de cuyo análisis se concluye que la mayoría de las intervenciones utilizadas resultan de alguna utilidad para mejorar el ajuste psicológico tanto de los niños como de los padres, aunque el número de tratamientos que pueden considerarse realmente eficaces es más limitado. Se discute sobre la conveniencia de que la intervención psicológica dirigida a este tipo de población se centre más en las fortalezas y en la promoción de la salud y deje de apoyarse exclusivamente en modelos de tratamiento basados en déficits y psicopatología. Posiblemente, este cambio de orientación contribuirá a fomentar cambios clínicamente relevantes en relación al estrés que acompaña al cáncer y su tratamiento.

Palabras clave: Ajuste psicológico, intervenciones, cáncer infantil, revisión.



Childhood cancer is the second cause of death worldwide, after accidents only. According to data from the Spanish National Statistics Institute (2011), the incidence of cancer in the 0-19 years old population in 2008 was 124 cases per million inhabitants, with 36,31 deaths per million. These rates are very similar to those of the European Union, where mortality rates are approximately 34,5 per million children (Eurostat, 2011).

The disease's diagnosis involves a wearing process, generating high levels of stress, and causing changes in all areas, including health related behavior (Valencia, Flores & Sanchez, 2006). Treatment is also a difficult process, since it includes invasive and painful medical procedures, some of which imply a life threat (Aldridge & Roesch, 2007). In spite of such evidence, survival rates for children between 0 and 14 years old in Spain are good: 79% of cases 3 years after diagnosis and 77% of those within five years after diagnosis (National Institute of Statistics, 2011).

With regard to family's adjustment, research shows higher vulnerability to anxiety, depression and physical illness. This is particularly significant for mothers, who are the main caregivers and have to handle with, in addition to daily demands, healthcare demands, fear of death and other family or financial issues (Sahler et al., 2005).

Cancer and psychological adjustment

A large body of research on psychological adjustment of children with cancer (under treatment or survivors) indicates that this population is well adapted to the situation, suggesting that: i) they do not show higher levels of anxiety, depression, worse body image or lower self esteem than same aged "healthy" children; ii) they do not have fewer social peer relationships, are less popular, or have a worse quality of life than "healthy peers". Both conclusions hold in the early stages of the disease and in the longterm, considering different ages (Barakat et al., 2003; Barakat, Kazak, Gallagher, Meeske & Stuber, 2000; Bragado, Hernández-Lloreda, Sanchez-Bernardos & Urban, 2008; Chao, Chen, Wang, Wu & Yeh , 2003; Fuemmeler, Brown, Williams & Potter, 2003; Langeveld, Stam, Grootenhuis & Last, 2002; Kazak, 2005; Meeske, Ruccione, Globe & Stuber, 2001; Newby, Brown, Pawletko, Gold & Whitt, 2000 , Orbuch, Parry, Chesler, Fritz & Repetto, 2005; Phipps, Jurbergs & Long, 2009; Seitz, Besier & Goldbeck, 2009; Sorgen & Manne, 2002). These findings are usually interpreted through the prism of resilience, generally defined as the ability to cope and function normally in adverse contexts (Bragado, 2009).

However, some studies suggest that the good adjustment found in these children could be attributed to the use of a "repressive" coping style (which would lead them to report fewer symptoms than they have actually experienced). This way of coping with their condition implies that these children are not fully aware of their symptoms, or that scientific approaches have used insensitive measures to their psychological problems (such as PTSD measures). In line with this argument, several papers report that children with cancer employ a repressive or a denial style at higher rates than healthy controls, and that this style is likely to remain until adulthood (Erickson & Steiner, 2001; Fuemmeler et al., 2003; Phipps, Larson, Long & Rai, 2006; Phipps et al., 2009). Nonetheless, this coping style should not always be considered as a negative feature, since data suggest that avoidant strategies may be very adaptive in certain situations, such as those included in cancer treatment (diagnosis, painful medical procedures) (Aldridge & Roesch, 2006; Phipps, 2007). Hence, as Kupst and Patenaude (2005) point out, it seems that there are not optimal coping strategies, but different ways of dealing with the situation, which may vary according to specific circumstances and individual characteristics.

In a similar vein, Maurice-Stam et al. (2009) suggest that this good adaptability may be due to a "response shift", meaning that the experience of having cancer may change the way children conceptualize problems, so that they see fewer problems than before. It is also possible that these children's adjustment is a consequence of using appropriate family coping strategies, as we can see on survivors of childhood cancer, who report an emotional growth after the disease, as well as feelings of happiness, wellbeing, hope, life satisfaction, greater proximity to family, greater appreciation of life, more future perspectives and higher quality of life (Chao et al., 2003, Erickson & Steiner, 2001; Meeske et al., 2001).

Despite this overall good performance, there is a small subgroup (10% - 30%), generally comprehending children who have suffered some damage in the CNS (as a result from the tumor or the treatment), who have a wide range of clinical significant psychological problems, such as: depressive symptoms, somatic, anxiety and low self esteem, ineffective coping, school, family, social or work problems (Barakat al., 2003; Grootenhuis & Last, 1997; Kazak, 2005; Kazak et al., 2003, Maurice-Stam, Oort, Last & Grootenhuis, 2008; Newby et al., 2000; Patenaude & Kupst, 2005; Robinson, Gerhardt, Vannata & Noll, 2009; Seitz et al., 2009).

Parents' psychological adjustment

Having a child diagnosed with cancer is one of the most severe stressors parents may experience during parenting process (Jurbergs, Long, Ticona & Phipps, 2009). Some studies have found high rates of PSTD symptoms in parents of children with cancer, ranging up to 60% when assessing the overall stress (Kazak et al., 2004, Robinson et al., 2009). In general, according to several studies, it could be stated that parents have more adjustment problems than their children (Phipps et al., 2006), as they present elevated levels of PTSD. These symptoms tend to remain stable up to two years after diagnosis, even though they usually decline after this period, reaching levels of stress comparable to the ones of the general population (Phipps, Long, Hudson & Rai, 2005).

On the other hand, other publications present a better scenario, indicating that parents are optimistic and that the experience of having a child with cancer made them become emotionally stronger, selecting new priorities in life and giving them a greater sense of personal force, an improvement in relationships and a better management of other stressors (Barakat et al., 2003, Barakat et al., 2000, Fernandez et al., 2009; Grootenhuis & Last, 1997; Jurbergs et al. 2009, Maurice-Stam et al., 2008). Kazak et al. (2007) believe that parents' stress can be adaptive, since it alerts their social environment that they are in need of emotional support. Denial or avoidance can be also adaptive, helping these parents to tolerate stress and to fulfill their parental responsibilities, coping with emotional and treatment demands.

Therefore, childhood cancer affects physically and psychologically not only the child, but his/her entire family. This is the reason why it is necessary to develop effective interventions that promote health and help mitigating the psychological consequences of the disease, as well as reducing associated healthcare costs. Research in this field has experienced a remarkable, though slow, growth, probably due to the increase of survival rates in addition to higher scientific and government interest in improving health care for these children and their families.

Research goal

This paper aims at providing an overview of the effectiveness of psychological interventions designed to promote children with cancer or survivors' adjustment and their parents'. To fulfill this purpose, we reviewed all published articles on this particular field within the 1998-2010 period.




In order to achieve the proposed goal, our search focused on the following databases: PsycINFO, Medline, SciELO, LILACS, Psyarticles and Psicodoc. This particular choice is supported by the relevance and impact of publications contained in these repositories, thus representing sources for the most significant literature related to our assessment.

Key word used to detect specific publications were: psychosocial intervention, psychotherapy, trial, treatment, adjustment, well being, adaptation, cancer, childhood cancer, pediatric cancer, anxiety, and depression. These terms were combined in different ways, in order to provide our search with more robust results. These descriptors were chosen according to the thesaurus of different databases, restricting the search to articles published in scientific journals, including literature in both English and Spanish.


Out of the articles found with the above mentioned key words, we excluded those related to interventions with siblings, teachers, doctors or parents with cancer, qualitative or descriptive studies, the ones exploring nonpsychological aspects of the disease, as well as theoretical reviews or meta analytical ones.

Articles' inclusion considered the following aspects: that the intervention would promote psychological adjustment of children with cancer (patients or survivors) or their parents', that the article had been published within the time range mentioned above and that it contained any of the selected keywords. Therefore, we included randomized and nonrandomized controlled trials (longitudinal or crosssection) and prepost studies (those that compare results obtained before and after the intervention).

Regarding participants, we considered only studies who used parents of children affected by cancer, survivors of cancer, or patients themselves (children or adolescents) aged below 18 years old, in the case of patients, and not exceeding 21 in the case of survivors (defined as patients who remained in remission, without treatment, for at least one year).

Finally, journals containing articles with the abovementioned descriptors were: European Journal of Oncology Nursing, Health Education, Journal of Consulting and Clinical Psychology, Journal of Family Psychology, Journal of Pediatric Oncology Nursing, Journal of Pediatric Psychology, Psychooncology, Journal of Behavior Analysis and Scandinavian Journal of Caring Sciences.



Characteristics of selected articles

Fourteen articles met the criteria and involved a total of 509 children and adolescents, aged 6 months to 20 years old (mean: 12 years old), and 958 adults (parents or caregivers) aging 38 years old on average. The most common children's diagnoses were hematologic malignancies (leukemia, lymphomas), followed by sarcomas and brain tumors. Most participants were from the United States (9 studies), while the remaining studies (5 assessments) were distributed among different countries: Canada, Netherlands, Australia, Iceland and Mexico.

Eight articles were RCTs, in which interventions' effects (present in the experimental group) were compared to control groups' changes. This latter group received either standard care (Hoekstra-Weebers, Heuvel, Jaspers, Kamps & Slip, 1998; Kazak et al., 2005; Sahler et al., 2005; Streisand, Rodrigue, Houck, Graham-Pole & Berlant, 2000), a psychological placebo (Hinds et al. , 2000, Schwartz & Drotar, 2004), or remained on the waiting list without treatment (Butler et al, 2008; Kazak et al., 2004). Six studies used a prepost design without control groups (Barakat et al., 2003; Barrera, Rykov & Doyle, 2002; McCaffrey, 2006; Svavardottir & Sigurdardortti, 2005; Thygeson, Hooke, Claspsaddle, Robbins & Moquist, 2010; Valencia et al., 2006).

42.85% of the reviewed articles focused on interventions only for parents or caregivers (Hoekstra-Weebers et al., 1998; Kazak et al., 2005; Sahler et al., 2005, Schwartz & Drotar, 2004; Streisand et al., 2000; Svavardottir & Sigurdardortti, 2005), while 35.71% were intended only for children / adolescents (Barakat et al., 2003; Barrera et al., 2002, Butler et al, 2008; Hinds et al., 2000, McCaffrey, 2006). The remaining 21.43% approached both cohorts (parents and children), with joint or separate sessions (Kazak et al., 2004; Thygeson et al., 2010, Valencia et al., 2006). A summary of the most relevant outcomes of these studies is offered in Appendix 1.


Regarding the assessment instruments (outcomes) one aspect that deserves attention concerns its diversity. Few researchers used the same instruments to assess similar psychological variables (stress, self esteem, quality of life and negative affect). Only four instruments were used in more than one study: the State Trait Anxiety Inventory STAI (4 studies), Impact of Events Scale - Revised - IESR (3 studies), the Revised Children's Manifest Anxiety Scale - RCMAS (2 studies) and the Profile of Mood States - POMS (2 studies).


In the same vein of assessments, intervention procedures were also diverse. Most (77.7%) interventions undertaken with parents focused on reducing stress and emotional distress caused by cancer diagnosis (4 studies) or children's hospitalization (3 studies). Treatments included teaching a myriad of coping skills: problem solving, communication skills, stress inoculation, writing about the experience and cognitive restructuring. The latter item represented the most widespread technique within our sample of articles (4 studies).

Cognitive restructuring strategy was also the most used technique with children (3 studies), followed by social skills training, teaching coping strategies and / or selfcare and relaxation, where each approach was applied in two studies. Interactive music therapy and cognitive rehabilitation could be identified in one approach each.

The number and duration of sessions, in both cases (children and parents), was highly variable, ranging from a single 40 minute session (Hinds et al., 2000) up to twenty 2 hour sessions (Butler et al. 2008), hampering the extraction of an overall pattern in this regard. Sessions were mostly individual (83.3% of the reviewed articles - see Appendix 1).

Interventions' effectiveness

To assess interventions' effectiveness, the total or partial achievement of therapeutic goals was taken as a benchmark. With this concept in mind, our results suggest that the majority (75.21%) of the proposed treatments had some effect on the participant's psychological adjustment. Specifically, 35.71% of the interventions were effective, since they produced significant changes in all outcome measures and therefore objectives were achieved. A similar percentage (37.5%) had partial or mixed effects, meaning that they produced changes only in some measures but not in others. The remaining interventions (28.57%) had no effect on adjustment measures, hence classified as ineffective. However, this scenario becomes rather blurry if the analysis of results focuses exclusively on randomized controlled studies: 50% of these interventions were ineffective, against 25% of fully effective ones and another 25% of partially effective ones.

Concerning children's interventions (patients or cancer survivors), most of them (62.5%) produced mixed results (Barrera et al., 2002, Butler et al., 2008; Kazak et al., 2004; McCaffrey 2006; Thygeson et al., 2010). The best results were obtained through the interventions proposed by Barakat et al. (2003) and Valencia et al. (2006), which could be classified as effective (25.5%). The worst attainments were related to the work of Hinds et al. (2000), which had no significant effects on the outcome measures (12.5%).

Regarding the "effective" interventions, Barakat el al. (2003) improved functioning and social skills of 13 survivors, mean age 10.7 years old, who had been treated for a brain tumor. The authors used a social skills training program (communication, giving and receiving compliments, conflict resolution, empathy and cooperation), reinforced with a parental component. Valencia et al. (2006) were able to increase adherence, self care behaviors, assertive skills and optimism in a group of 6 children (5-15 years-old). They used a cognitive behavioral program, that consisted on cognitive restructuring, skills training and assertive and decatastrophizing training and also problem solving, reinforced with teaching parents the basics of behavioral analysis. However, it must be highlighted that evidence on the effectiveness of these interventions is mainly for pre post studies, which may raise some concerns about the practical contribution of these findings.

None of the treatments offered to children included in the three randomized controlled studies can be considered effective, since two had mixed results (Butler et al., 2008; Kazak et al., 2004) and the other (as previously mentioned) provided no improvements (Hinds et al., 2000). In the latter case, the authors did not find statistically significant differences between the experimental treatment (information on selfcare coping teaching coping strategies using filmed modeling and behavioral rehearsal) and control group (placebo care), in any of the adjustment measures, or any of the postintervention measurements (3 time points).

In relation to results obtained with parents, evidence seems more consistent. 44.44% of psychological treatments produced positive and statistically significant effects on out comes, compared with those found in control groups (Kazak et al., 2005; Sahler et al., 2005) or with previous levels of the participants at baseline (Thygeson et al., 2010, Valencia et al., 2006). 22.22% obtained mixed results (significant changes in some adjustment measures, but not in others) (Kazak et al., 2004; Svavardottir & Sigurdardortti, 2005) and 33.33% produced no effects (Hoekstra-Weebers et al. 1998; Drotar & Schwartz, 2004; Streisand et al., 2000).

Unlike the results with children's interventions, 33.33% of parents' RCTs (6 studies) showed that these treatments were effective in achieving their objectives (Kazak et al., 2005; Sahler et al., 2005), while 16.7% produced mixed results (Kazak et al. 2004) and 50% did not yield any therapeutic benefits (Hoekstra-Weebers et al., 1998, Schwartz & Drotar, 2004; Streisand et al., 2000).

The two "effective" treatments had the intention of reducing posttraumatic stress and emotional symptoms on parents of newly diagnosed children. Kazak et al. (2005) used a modification of Surviving Cancer Competently Intervention Program, developed by the authors, mainly composed of a cognitive restructuring strategy and discussion of personal growth and future. Sahler et al. (2005) used problem solving training, which consisted on discussing the problems that really disturbed parents during this phase of disease.



As previously outlined, the underlying goal of our assessment is to review the effectiveness of psychological interventions designed to improve the adjustment of children suffering from cancer and their parents'. We have identified a total of 14 articles that met the inclusion criteria. Considering the results as a whole, they are promising but inconclusive and difficult to interpret, due to the high variability regarding the objectives between studies, the interventions used to achieve them, the measures chosen to measure the effects and the selected samples. Therefore, it is not surprising that, although most interventions showed some therapeutic effect, the ones that can be defined as effective are few. Only one quarter of interventions targeting children produced statistically significant changes in all measures of adjustment, compared to almost twice of those offered to parents. However, this general pattern can be misleading: if we take into account only randomized trials, we can verify that none of the treatments applied to children was fully effective, but mostly they produced mixed results. For parents, data seemed more consistent, suggesting that they benefit more from psychological interventions than their offspring.

In general, our results are consistent with those reported in other published works (Davey & Neff, 2001; Pai, Drotar, Zebracki, Moore & Youngstrom, 2006; Robinson et al., 2009; Seitz et al., 2009). Specifically, the meta analysis performed by Pai et al. (2006), using 12 articles published between 1983 and 2005, indicated that interventions targeting children had no significant effect on distress or adjustment measures, while those employed with parents showed a modest, but statistically significant effect. Meanwhile, Seitz et al. (2009) reviewed psychological interventions' effectiveness to reduce psychological distress and / or improve psychosocial adjustment of adolescents with cancer. Of four articles, only one presented statistically significant changes when comparing the experimental treatment with a waiting list control.

It is possible that the small number of effective interventions for children and adolescents is related to their psychological status before the intervention. As previously stated, recent research data indicate that most children with cancer are psychologically well adapted to the disease and its treatments, while most parents suffer from adjustment problems for at least two years after diagnosis. This suggests that psychological treatments used with children were not fully effective for a possible "ceiling effect", i.e., children already presented a good adjustment before starting the treatment and, consequently, it had few significant changes, perhaps because there was nothing else to improve. Instead, more significant effects were obtained with parents because they probably had some clinical psychological problems before the intervention.

On the other hand, considering the elevated number of mixed results with children, it is also possible that therapeutic goals were not well defined, and maybe they do not meet the real needs and concerns of the child, and this is a possible explanation for why these interventions have caused only partial effects. Several researchers have drawn attention to the need of adapting interventions to specific demands of this specific population as well as to a better definition of therapy focus (Butler et al., 2008, Hastings & Beck, 2004; Patenaude & Kupst, 2005).

One aspect that deserves consideration related to therapy focus is whether the involvement of parents in their children's treatment - or dealing with psychological problems of both of them at the same time - would improve the effectiveness of interventions. It seems well established in the scientific literature that children's emotional distress symptoms (anxiety, depression and PTSD) are highly associated with their parents' suffering (Phipps et al., 2005; Robinson, Gerhardt, Vannatta & Noll, 2007; Robinson et al., 2009). As a consequence, it is predictable that intervening on both parents and children would produce greater therapeutic effect. Although data from our review do not clarify this issue completely, they do point in this direction, since one third of the studies with positive results (efficient or mixed) intervened with parents and children at the same time, while none of the ineffective did. Unfortunately, it is unknown whether efficient treatments directed only to parents or only to children had any effect on psychological well being of the other side, since this feature was not considered in the objectives of studies and therefore appropriate measures were not included.

However, the greatest restraint to draw more conclusive results comes from methodological difficulties, common in this research field and that limits the comparison between studies. The first problem is related to the study design. Much of the improvement (total or partial) comes from pre post studies, hindering us to know whether changes in the adjustment measures are due to the intervention's effect or to other circumstances, since there is not a control group to compare with. Indeed, interventions that showed no significant changes in adjustment measures were randomized studies. The control type used in these randomized studies is another point to be considered: although eight from the total reviewed articles applied this design, only two used a placebo care group equivalent to the experimental group; others chose a waiting list or standard care. As pointed out by other authors (Pai et al., 2006; Scott Harmsen, Sowden & Watt, 2008), a waiting list cannot control nonspecific effects derived from the intervention, so that it cannot be assessed if the simple fact of offering qualified care by the therapist at a particularly stressful situation is enough to improve participants' adjustment. This issue hampers the evaluation of the exact extent of the treatment. Interestingly, the only two studies using psychological placebo to determine experimental treatments' effectiveness found no differences between groups (Hinds et al., 2000, Schwartz & Drotar, 2004), reinforcing the need of more robust methodologies.

The second problem that limits our comparison and generalization of the results is related to samples' heterogeneity, both in relation to children's age (highly dispersed), and to the situation in which they were at the time of the study (survivors, newly diagnosed, hospitalized for various reasons, etc.), with significant differences between them, even with the ones that are in the same situation. For example, the time that survivors were without treatment ranged from one to twelve years, the reasons for hospitalization were very irregular: diagnosis, chemotherapy, treatment side effects, bone marrow transplant, relapse, etc. All this variability, together with the interventions' diversity (treatments, number and duration of sessions, etc.), makes it almost impossible to define properly which treatment is more effective and for which patients.

Also, it is not an easy task to establish if the outcomes of interventions that showed some therapeutic effect are maintained in the long term. Out of six studies that reported prepost favorable results (total or partial), only one evaluated the treatment effect nine months later. And while all randomized trials that obtained positive results (4 studies) conducted a followup, the mean duration of it was less than four months (range 3-6 months).

It is likely that most of these methodological limitations are determined by inherent difficulties of psychological research, particularly in psychooncology. Both recruitment process of the initial sample as its longterm maintenance represent particularly arduous tasks, taking into account the situation of the affected individuals (parents and children), and its expensiveness, personally and economically. These difficulties may increase if we try to randomize participants for treatment or control groups. The moderate acceptance rate found in most of the reviewed articles, which tends to be below 60% of contacted individuals, supports this idea. The most common reasons given for not cooperating were: lack of time to meet the research's demands, feeling overwhelmed and lack of interest. To ensure participants' collaboration, some researchers (Sahler et al., 2005) resorted to financial compensation, delivering $ 100 to each participant at the end of the evaluation, making the rate of acceptance rise (75%). A debatable, but considerable solution, in order to encourage participation in future researches.

Also considering future studies, efforts should be made in order to improve the offer and effectiveness of interventions for both children and parents. For this purpose, it is necessary to first identify what are their needs and demands, and then develop a treatment plan designed to meet them, analyzing its effects in the short and long terms. According to this perspective, some authors (Hinds et al., 2000; Hoekstra Weebers et al., 1998; Kazak et al., 2005, Pai et al., 2006, Robinson et al., 2009) suggest that psychological treatments should be more flexible and responsive to participants' concerns, their specific set of coping styles, taking into account the treatment phase and focusing on achieving specific results and not general ones. Other authors (Aslett, Levitt, Richardson & Gibson, 2007; Kazak, 2005; Hobbie et al., 2000) suggest that psychological interventions should avoid relying solely on treatment models based on deficits or psychopathologies, as the posttraumatic stress model. Although this model has been influential in this field of study, it has also been questioned by several researchers (Erickson and Steiner, 2001; Jurbergs et al., 2009; Phipps et al., 2009) who propose focusing on strengths and psychological health promotion, in order to achieve clinically relevant changes in stress derived from cancer and its treatment. In this sense, Kazak et al. (2007) discussed the need for a general therapeutic model that should offer preventive and innovative treatments that are also targeted to the real needs of the child and his family. This model should include psychosocial interventions addressed on promoting family's competence and identifying families who are at psychological risk. As pointed out by these authors, the ultimate goal of psychological care and cure of childhood cancer is that children and adolescents suffering from the disease could reach adulthood in the best possible conditions: with resilience, autonomy, quality of life and accepted by the society at the same level as their peers.



The first remarkable conclusion from our review is that most of the psychological interventions offered to children and parents produced some therapeutic benefit, although the number of really effective treatments is limited, especially the ones offered to children. This result raises some questions about the objectives' appropriateness, the techniques employed and the selected measurement instruments. Determining therapy focus or its convenience are two pending issues in pediatric psychooncology field that have caused some debate among experts, including some believing that it is unnecessary to improve psychological adjustment of children, as they are particularly well adapted to cancer circumstances. About this issue, our review suggests that the effectiveness of children interventions could be improved if we involve parents in the process, something which there is little consensus about. Some researchers argue that parents care would be sufficient to improve the children's adjus tment (Hastings & Beck, 2004), while others seem to be favorable to a joint intervention (Barakat, Lutz, Nicolaou & Lash, 2005; Fuemmeler et al., 2003; Klassen et al., 2011 , Landolt, Vollrath, Niggli, Gnehm & Sennhauser., 2006) and a third group claims that there is no relationship between improvement of children and parents (Grootenhuis & Last, 1997; Lutz, Barakat, Smith Whitley & Ohene-Frempong, 2004; Robinson et al., 2007).

The small number of articles found in our approach, as well as the great variability regarding treatment techniques, number of sessions, outcome measures and samples, hinders drawing specific conclusions and highlights the importance of continuous investigation in this area. Future research should clarify the concept of psychological adjustment and the relevance of interventions, and to embrace a longterm approach of interventions' effectiveness, thus overcoming the methodological difficulties mentioned in the discussion.



1. Aldridge, A.A. y Roesch, S. (2007). Coping and adjustment in children with cancer: A metaanalytic study. Journal of Behavioral Medicine, 30 (2), 115-129. doi: 10.1007/s10865-006-9087-y.         [ Links ]

2. Aslett, H., Levitt, G., Richardson, A. y Gibson, F. (2007). A review of long-term follow-up for survivors of childhood cancer. European Journal of Cancer, 43, 1781-1790. doi:10.1016/j.ejca.2007.04.009.         [ Links ]

3. Barakat, L. P., Hetzke, J. D., Foley, B., Carey, M. E. Gyato, K. y Phillips, P.. (2003). Evaluation of a social skills training group intervention with children treated for brain tumors: a pilot study. Journal of Pediatric Psychology, 28 (5), 299-307. doi: 10.1093/jpepsy/jsg019.         [ Links ]

4. Barakat, L.P., Lutz, M. J., Nicolaou, D. C. y Lash, L. A. (2005). Parental locus of control and family functioning in the quality of life of children with sickle cell disease. Journal of Clinical Psychology in Medical Settings, 12 (4), 323-331. doi: 10.1007/s10880-005-7818-9.         [ Links ]

5. Barakat, L. P., Kazak, A. E., Gallagher, P. R., Meeske, K. y Stuber, M. (2000). Posttraumatic stress symptoms and stressful life events predict the longterm adjustment of survivors of childhood cancer and their mothers. Journal of Clinical Psychology in Medical Settings, 7 (4), 189-196. doi: 10.1093/jpepsy/jsj016.         [ Links ]

6. Barrera, M. E., Rykov, M. H. y Doyle, S. L. (2002). The effects of interactive music therapy on hospitalizad children with cancer: a pilot study. Psychooncology, 11, 379-388. doi: 10.1002/pon.589.         [ Links ]

7. Bragado, C. (2009). Funcionamiento psicosocial e intervenciones psicológicas en niños con cáncer. Psicooncología, 6 (2-3), 327-341.         [ Links ]

8. Bragado, C., Hernández-Lloreda, M. J., Sánchez-Bernardos, M. L. y Urbano, S. (2008). Autoconcepto físico, ansiedad, depresión y autoestima en niños con cáncer y niños sanos sin historia de cáncer. Psicothema, 20 (3), 413-419.         [ Links ]

9. Butler, R. W., Copeland, D. R., Fairclough, D. L., Mulhern, R. K., Katz, E. R., Kazak, A. E., Noll, R. B., Patel, S. K. y Sahler, O. J. Z. (2008). A multicenter, randomized clinical trial of a cognitive remediation program for childhood survivors of pediatric malignancy. Journal of Consulting and Clinical Psychology, 76 (3), 367-378. doi: 10.1037/0022-006X.76.3.367.         [ Links ]

10. Chao, C., Chen, S., Wang, C., Wu, Y. y Yeh, C. (2003). Psychosocial adjustment among pediatric cancer patients and their parents. Psychiatry and Clinical Neurosciences, 57, 75-81. doi: 10.1046/j.1440-1819.2003.01082.x.         [ Links ]

11. Davey, T. L. y Neff, J. A. (2001). A shelter based stress reduction group intervention targeting self esteem, social competence, and behavior problems among homeless children. Journal of Social Distress and the Homeless, 10 (3), 279-291.         [ Links ]

12. Erickson, S. J. y Steiner, H. (2001). Trauma and personality correlates in long term pediatric cancer survivors. Child Psychiatry and Human Development, 31 (3), 195-213.         [ Links ]

13. Eurostat (2011). Disponible en: Recuperado el 21/10/11.         [ Links ]

14. Fernández, B., Llorens, A., Arcos, L., García, R., Zabalza, A. y Jorge, V. (2009). Calidad de vida y estado de salud en niños y en adolescentes supervivientes de cáncer. Psicooncología, 6 (2-3), 459-468.         [ Links ]

15. Fuemmeler, B. F., Brown, R. T., Williams, L. y Barredo, J. (2003). Adjustment of children with cancer and their caregivers: moderating influences of family functioning. Families, Systems y Health, 21 (3), 263-276. doi: 10.1037/1091-7527.21.3.263.         [ Links ]

16. Grootenhuis, M. A. y Last, B. F. (1997). Predictors of parental emotional adjustment to childhood cancer. Psycho Oncology, 6, 115-128.         [ Links ]

17. Hastings, R. P. y Beck, A. (2004). Practitioner review: stress intervention for parents of children with intellectual disabilities. Journal of Child Psychology and Psychiaty, 45 (8), 1338-1349. doi: 10.1111/j.1469-7610.2004.00357.         [ Links ]

18. Hinds, P. S., Quargnenti, A., Bush, A. J., Pratt, C., Fairclough, D., Rissmiller, D. B. y Gilchrist, G. S. (2000). An evaluation of the impact of a self-care coping intervention on psychological and clinical outcomes in adolescents with newly diagnosed cancer. European Journal of Oncology Nursing, 4 (1), 6-17. doi:10.1054/ejon.1999.0051.         [ Links ]

19. Hobbie, W. L., Stuber, M., Meeske, K., Wissler, K., Rourke, M. T., Ruccione, K., Hinkle, A. y Kazak, A. E. (2000). Symptoms of posttraumatic stress in young adult survivors of childhood cancer. Journal of Clinical Oncology, 18 (24), 4060-4066.         [ Links ]

20. Hoekstra-Weebers, J. E. H. M., Heuvel, F., Jaspers, J. P. C., Kamps, W. A. y Klip, E. C. (1998). Brief report: an intervention program for parents of pediatric cancer patients: a randomized controlled trial. Journal of Pediatric Psychology, 23 (3), 207-214. doi: 10.1093/jpepsy/23.3.207.         [ Links ]

21. Instituto Nacional de Estadística (2011). Disponible en Recuperado el 21/10/11.         [ Links ]

22. Jurbergs, N., Long, A. L., Ticona, L. y Phipps, S. (2009). Symptoms of posttraumatic stress in parents of children with cancer: are they elevated relative to parents of healthy children? Journal of Pediatric Psychology, 34 (1), 4-13. doi: 10.1093/jpepsy/jsm119.         [ Links ]

23. Kazak, A. E. (2005). Evidence based interventions for survivors of childhood cancer and their families. Journal of Pediatric Psychology, 30 (1), 29-39. doi: 10.1093/jpepsy/jsi013.         [ Links ]

24. Kazak, A. E., Alderfer, M. A., Streisand, R., Simms, S., Rourke, M. T., Barakat, L. P., Gallagher, P. y Cnaan, A. (2004). Treatment of posttraumatic stress symptoms in adolescent survivors of childhood cancer and their families: a randomized clinical trial. Journal of Family Psychology, 18 (3), 493-504. doi: 10.1037/0893-3200.18.3.493.         [ Links ]

25. Kazak, A. E., Cant, M. C., Jensen, M. M., Mc Sherry, M., Rourke, M. T., Hwang, W., Alderfer, M. A., Beele, D., Simms, S. y Lange, B. L. (2003). Identifying psychosocial risk indicative of subsequent resource use in families of newly diagnosed pediatric oncology patients. Journal of Clinical Oncology, 21 (17), 3220-3225. doi: 10.1200/JCO.2003.12.156.         [ Links ]

26. Kazak, A. E., Rourke, M. T., Alderfer, M. A., Pai, A., Reilly, A. F. y Meadows, A. T. (2007). Evidence based assessment, intervention and psychosocial care in pediatric oncology: a blueprint for comprehensive services across treatment. Journal of Pediatric Psychology, 32 (9), 1099-1110. doi: 10.1093/jpepsy/jsm031.         [ Links ]

27. Kazak, A. E., Simms, S., Alderfer, M. A., Rourke, M. T., Crump. T., McClure, K., Jones, P., Rodriguez, A., Boeving, A., Hwang, W. y Reily, A. (2005). Feasibility and preliminary outcomes from a pilot study of a brief psychological intervention for families of children newly diagnosed with cancer. Journal of Pediatric Psychology, 30 (8), 644-655. doi: 10.1093/jpepsy/jsi051.         [ Links ]

28. Klassen, A., Raina, P., McIntosh, C., Sung, L., Klaasen, R. J., O'Donnell, M., Yanofsky, R. & Dix, D. (2011). Parents of children with cancer: which factors explain differences in health related quality of life. International Journal of Cancer, 129, 1190-1198. doi: 10.1002/ijc.25737.         [ Links ]

29. Landolt, M. A., Vollrath, M., Niggli, F. K., Gnehm, H. E. & Sennhauser, F. H. (2006). Health related quality of life in children with newly diagnosed cancer: a one year follow up study. Health and Quality of Life Outcomes, 4, 63-70. doi:10.1186/1477-7525-4-63.         [ Links ]

30. Langeveld, N. E., Stam, H., Grootenhuis, M. A. y Last, B. F. (2002). Quality of life in young adult survivors of childhood cancer. Support Care Cancer, 10, 579-600. doi: 10.1007/s00520-002-0388-6.         [ Links ]

31. Lutz, M. J., Barakat, L. P., Smith-Whitley, K. y Ohene-Frempong, K. (2004). Psychological adjustment of children with sickle cell disease: family functioning and coping. Rehabilitation Psychology, 49 (3), 224-232. doi: 10.1037/0090-5550.49.3.224.         [ Links ]

32. Maurice-Stam, H., Oort, F. J., Last, B. F. y Grootenhuis, M. A. (2008). Emotional functioning of parents of children with cancer: the first five years of continuous remission after the end of treatment. Psycho-Oncology, 17, 448-459. doi: 10.1002/pon.1260.         [ Links ]

33. Maurice-Stam, H., Oort, F. J., Last, B. F., Brons, P. P. T., Caron, H. N. y Grootenhuis, M. A. (2009). School aged children after the end of successful treatment of noncentral nervous system cancer: longitudinal assessment of health related quality of life, anxiety and coping. European Journal of Cancer Care, 18, 401-410. doi: 10.1111/j.1365-2354.2008.01041.x.         [ Links ]

34. McCaffrey, C. N. (2006). Implementation and evaluation of the modified feeling great program for oncology children. Health Education, 106 (4), 294-308. doi: 10.1108/09654280610673472.         [ Links ]

35. Meeske, K. A., Ruccione, K., Globe, D. R. y Stuber, M. L. (2001). Posttraumatic stress, quality of life, and psychological distress in young adult survivors of childhood cancer. Oncology Nurse Forum, 28 (3), 481-489.         [ Links ]

36. Newby, W. L., Brown, R. T., Pawletko, T. M., Gold, S. H. y Whitt, J. K. (2000). Social skills and psychological adjustment of child and adolescent cancer survivors. Psycho Oncology, 9, 113-126. doi:10.1002/(SICI)1099-1611(200003/04)9:2<113::AID-PON432>3.0.CO;2-F.         [ Links ]

37. Orbuch, T. L., Parry, C., Chesler, M., Fritz, J. y Repetto, P. (2005). Parentchild relationships and quality of life: resilience among childhood cancer survivors. Family Relations, 54 (2), 171-183. doi: 10.1111/j.0197-6664.2005.00014.x.         [ Links ]

38. Pai, A. L. H., Drotar, D., Zebracki, K., Moore, M. y Youngstrom, E. (2006). A meta analysis of the effects of psychological interventions in pediatric oncology on outcomes of psychological distress and adjustment. Journal of Pediatric Psychology, 31 (9), 978-988. doi: 10.1093/jpepsy/jsj109.         [ Links ]

39. Patenaude, A. F. y Kupst, M. J. (2005). Psychosocial functioning in pediatric cancer. Journal of Pediatric Psychology, 30 (1), 9-27. doi: 10.1093/jpepsy/jsi012.         [ Links ]

40. Phipps S. (2007). Adaptative style in children with cancer: Implications for a Positive Psychology approach. Journal of Pediatric Psychology, 32 (9), 10551066. doi: 10.1093/jpepsy/jsm060.         [ Links ]

41. Phipps, S., Jurbergs, N. y Long, A. (2009). Symptoms of post traumatic stress in children with cancer: does personality trump health status? Psycho Oncology, 18 (9), 992-1002. doi: 10.1002/pon.1496.         [ Links ]

42. Phipps, S., Larson, S., Long, A. y Rai, S. N. (2006). Adaptative style and symptoms of posttraumatic stress in children with cancer and their parents. Journal of Pediatric Psychology, 31 (3), 298-309. doi:10.1093/jpepsy/jsj033.         [ Links ]

43. Phipps, S., Long, A. Hudson, M. y Rai, S. N. (2005). Symptoms of Post Traumatic Stress in children with cancer and their parents: effects of informant and time from diagnosis. Pediatric Blood Cancer, 45, 952-959. doi: 10.1002/pbe.20373.         [ Links ]

44. Robinson, K. E., Gerhardt, C. A., Vannatta, K. y Noll, R. B. (2009). Survivors of childhood cancer and comparison peers: the influence of early family factors on distress in emerging adulthood. Journal of Family Psychology, 23 (1), 23-31. doi: 10.1037/a0014199.         [ Links ]

45. Robinson, K. E., Gerhardt, C. A., Vannatta, K. y Noll, R. B. (2007). Parent and family factors associated with child adjustment to pediatric cancer. Journal of Pediatric Psychology, 32 (4), 400-410. doi:10.1093/jpepsy/jsl038.         [ Links ]

46. Sahler, O. J. Z., Fairclough, D. L., Phipps, S., Mulhern, R. K., Dolgin, M. J., Noll, R. B., Katz, E. R., Varni, J. W., Copeland, D. R. y Butler, R. W. (2005). Using problem solving skills training to reduce negative affectivity in mothers of children with newly diagnosed cancer: report of a multisite randomized trial. Journal of Consulting and Clinical Psychology, 73 (2), 272-283. doi: 10.1037/0022-006X.73.2.272.         [ Links ]

47. Schwartz, L. y Drotar, D. (2004). Effects of written emotional disclosure on caregivers of children and adolescents with chronic illness. Journal of Pediatric Psychology, 29 (2), 105-118. doi: 10.1093/jpepsy/jsh014.         [ Links ]

48. Scott, J. T., Harmsen, M., Prictor, M. J., Sowden, A. J. y Watt, I. (2008). Intervenciones para mejorar la comunicación con niños y adolescentes acerca del cáncer que presentan (revisión Cochrane traducida). La Biblioteca Cochrane Plus, 4. Oxford: Update Software Ltd.         [ Links ]

49. Seitz, D. C. M., Besier, T. y Goldbeck, L. (2009). Psychosocial interventions for adolescent cancer patients: a systematic review of the literature. Pyscho Oncology, 18, 683-690. doi: 10.1002/pon.1473.         [ Links ]

50. Sorgen, K. E. y Manne, S. L. (2002). Coping in children with cancer: examining the goodness of fit hypothesis. Children's health care, 31 (3), 191-207. doi: 10.1207/S15326888CHC3103_2.         [ Links ]

51. Streisand, R., Rodrigue, J. R., Houck, C., Graham-Pole, J. y Berlant, N. (2000). Brief report: parents of children undergoing bone marrow transplantation: documenting stress and piloting a psychological intervention program. Journal of Pediatric Psychology, 25 (5), 331-337. doi: 10.1093/jpepsy/25.5.331.         [ Links ]

52. Svavarsdottir, E. K. y Sigurdardortti, A. (2005). The feasibility of offering a family level intervention to parents of children with cancer. Scandinavian Journal of Caring Sciences, 19, 368-372. doi: 10.1111/j.1471-6712.2005.00360.x.         [ Links ]

53. Thygeson, M. V., Hooke, M. C., Claspsaddle, J., Robbins, A. y Moquist, K. (2010). Peaceful play yoga: serenity and balance for children with cancer and their parents. Journal of Pediatric Oncology Nursing 27 (5), 276-284. doi: 10.1177/1043454210363478.         [ Links ]

54. Valencia, A. I., Flores, A. y Sánchez, J. J. (2006). Efectos de un programa conductual para el cuidado de pacientes oncológicos pediátricos. Revista Mexicana de Análisis de la Conducta, 32 (2), 178-198.         [ Links ]



Amanda Muglia Wechsler.

Article received: 15-02-2012
Reviewed: 03-03-2013
Accepted: 03-03-2013

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License