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Revista Española de Enfermedades Digestivas

versión impresa ISSN 1130-0108

Rev. esp. enferm. dig. vol.103 no.12 Madrid dic. 2011 



Well differentiated giant retroperitoneal liposarcoma during the pregnancy

Liposarcoma retroperitoneal gigante bien diferenciado durante el embarazo


Key words: Giant liposarcoma. Pregnancy.

Palabras clave: Liposarcoma gigante. Embarazo.


Dear Editor,

We are reporting the case of a patient with a giant liposarcoma, during the pregnancy and the outcomes of both patients.


Case Report

A 35-year-old patient, pregnant, with history of two previous cesarean deliveries was referred to our service due the presence of an abdominal mass at 36 weeks of gestational age. The patient declined any other medical problems and stated that over the course of two years advised the growing of her abdomen but did not seek medical attention.

To the physical examination she was cachectic, with the presence of an evident mass extending from the right subcostal angle and part of the left side to the symphysis pubis, displacing the gravid uterus from the midline to the left side.

An ultrasound of the abdomen and pelvis revealed a fetal survey within normal limits with a biophysical profile of 8/8 and the presence of the abdominal mass displacing the intra-abdominal organs. During the moment of the ultrasound survey the patient started with uterine contractions and was transferred to the labor and delivery room, reason why a magnetic resonance image was not performed. In the labor and delivery area she was found in active phase of labor. Due the history of the two previous cesarean deliveries a cesarean delivery was performed, delivering a 3,200 grams infant with no signs of wasting. The oncology team biopsied the mass with preliminary frozen section report of lipoma vs. liposarcoma. Due the patient wasting condition and lack of final histological report the debulking surgery was postponed.

During the final debulking surgery a giant retroperitoneal mass found, measuring 52 x 40 x 35 cm and weighting 12,500 grams, respecting the surrounding organs (kidneys, ureter, inferior vena cava and the abdominal aorta) (Figs. 1 and 2). The final pathology report was for positive for malignancy (a well differentiated liposarcoma) with no signs of metastasis. One year after the surgery, the patient has no signs of recurrence.



The liposarcomas are malignant tumors that encompass the 15% of all the soft tissue tumors in the adults; being the retroperitoneal liposarcoma the most common one and usually more than 50% of all of them measuring more than 20 cm when they are detected.

Due the vague and unspecific symptoms, these tumors usually are difficult to identify if its size is not making it an evident diagnosis (2).

Some of the most common associated symptoms are the increase of the abdominal girth, early satiety, lower limbs edema or intestinal occlusion (3,4).

The use of magnetic resonance image and computed tomography are the preferred methods for starting the evaluation of these tumors and to assist to take an opportune surgical decision for the definitive treatment (4).

The World Health Organization has classified these tumors into four different histological groups: mixoid, pleomorphic, lipoblastic or round cells and the well differentiated or lipoma like, being the latest one the most common and the one with the best prognosis due its low trend to metastasize. Unfortunately there are not reports of this specific tumor during the pregnancy and this is probably due most of these tumors are found during the sixth decade of life (5).

The well differentiated liposarcomas have a high rate of local recurrence, increasing it's aggressively through an undifferentiating process in 17% of the cases (6).

The reports of liposarcomas during the pregnancy indicate that it is safe to postpone the surgical resection of the mass until fetal lung maturation or even waiting until the full term of the pregnancy.

These tumors are radiosensitive and adjuvant radiotherapy can be indicated but there are reports that when the surgical debulking is optimal the adjuvant radiotherapy does not improve the patients' survival (7).


Omar Felipe Dueñas-García1, Maricela Díaz-Sotomayor2 y Hugo Rico-Olvera3
1Department of Obstetrics and Gynecology. Bronx Lebanon Hospital Center.
Albert Einstein College of Medicine. New York, USA.
2Department of Neonatology and
3Department of Oncology. Instituto Nacional de Perinatología
Isidro Espinoza de los Reyes. Lomas Virreyes, Mexico DF.



1. Dei Tos AP. Liposarcoma: new entities and evolving concepts. Ann Diagn Pathol 2000;4:252-66.         [ Links ]

2. Linehan DC, Lewis JJ, Leung D, Brennan MF. Influence of biologic factors and anatomic site in completely resected liposarcoma. J Clin Oncol 2000; 18:1637-43.         [ Links ]

3. Haaga JR, Lanzieri CF, Sartoris DJ, Zerhouni EA. Computed tomography and magnetic resonance imaging of the whole body. St. Louis: Mosby; 1994;1314-5.         [ Links ]

4. Weiss SW, Goldblum JR. Enzinger and Weiss's Soft Tissue Tumors. 4th ed. St. Louis: Mosby; 2001.         [ Links ]

5. Singer S, Antonescu CR, Riedel E, Brennan MF. Histologic subtype and margin of resection predict pattern of recurrence and survival for retroperitoneal liposarcoma. Ann Surg 2003;238:358.         [ Links ]

6. Weiss SW, Vasantha KR. Well-differentiated liposarcoma (atypical lipoma) of deep soft tissue of the extremities, retroperitoneum, and miscellanous sites. Am J Surg Pathol 1992;16:1051-8.         [ Links ]

7. García Marín A, Martín Gil J, Sánchez Rodríguez T, Pérez Díaz MD, Turégano Fuentes F. Giant mixed-type perirenal fat liposarcoma. Rev Esp Enferm Dig 2010;102:221-2.         [ Links ]

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