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Revista Española de Enfermedades Digestivas

versión impresa ISSN 1130-0108

Rev. esp. enferm. dig. vol.105 no.6 Madrid jun. 2013 



Non granular laterally spreading tumor resected by endoscopic submucosal dissection: An unusual treatment for an atypical lesion

Tumor rectal de crecimiento lateral tipo no granular resecado mediante disección endoscópica submucosa pura: un tratamiento inusual para una lesión atípica



Enrique Vázquez-Sequeiros1, Takahisa Matsuda2, Naoko Maruyama3, Akiko Ono4, Héctor Gerardo Pian5, Beatriz Peñas1, José Ramón Foruny1, Juan Ángel González-Martín1, Daniel Boixeda-de-Miquel1, Rosario Carrillo-Gijón5, Javier Die-Trill6 and Agustín Albillos1

1Consulta de Alto Riesgo de Cáncer Colorrectal. Unidad de Endoscopia. Department of Gastroenterology. Hospital Universitario Ramón y Cajal. Madrid. Universidad de Alcalá, IRYCIS. Madrid, Spain.
2Endoscopy Division. National Cancer Center Hospital. Tokyo, Japan.
3Department of Gastroenterology. Fujita Health University University School of Medicine. Aichi, Japan.
4Department of Gastroenterology. Hospital Virgen de la Arrixaca. Murcia, Spain.
5Department of Pathology. Hospital Universitario Ramón y Cajal. Madrid. Universidad de Alcalá, IRYCIS. Madrid, Spain.
6Departmento of General and Digestive Surgery. Hospital Universitario Ramón y Cajal. Madrid. Universidad de Alcalá, IRYCIS. Madrid, Spain



Case report

We present the case of an 82 years old male, with a past medical history remarkable for colonic polypectomies until the year 2003 when, after being operated and radiated due to a prostate adenocarcinoma, the patient discontinued surveillance. He was referred for control colonoscopy in the year 2012, identifying a flat tumor with elevated margins and central depression (IIa + IIc Paris classification) (laterally spreading tumor: LST), measuring 35 mm and localized 15 mm from the anal verge (1) (Fig. 1 A and B). Biopsies from the lesion were diagnosed as tubular adenoma with high grade dysplasia. Careful examination of the lesion with magnification, chromoendoscopy (indigo carmine) and narrow band imaging/NBI, and lifting of the lesion with a mixture of glycerol/indigo/hyaluronic acid, determined that the lesion was not infiltrating the submucosa, and an endoscopic submucosal dissection (ESD) of the lesion was performed by experts in this technique (T.M./N.M.) as previously reported (2) (Fig. 2 A-C). For such purpose, Dual knife and IT-2 knife Olympus® were employed, achieving a complete resection of the lesion in one piece (Fig. 3). Pathology report of the resected lesion demonstrated high grade dysplasia/in situ carcinoma with no residual tumor on the margins of resection (Fig. 4), therefore as the tumor was not infiltrating the submucosa (limit point for lymphatic spread) it was considered that ESD had been curative, and more aggressive surgery was avoided (3).




LST of the colon (lesions with a short vertical axis and > 10 mm of lateral spread), may be classified as granular type (multiple nodules and less invasive) and non granular type (flat/plane, higher potential for infiltration), being this last one localized in the rectum in only a few number of patients (4). ESD performance is anecdotal in our country, as the learning curve for this technique is large and complicated, being necessary in our opinion to organize a teaching program for this difficult technique (5).



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3. Yamamoto S, Watanabe M, Hasegawa H, Baba H, Yoshinare K, Shiraishi J, et al. The risk of lymph node metastasis in T1 colorectal carcinoma. Hepatogastroenterology 2004;51:998-1000.         [ Links ]

4. Uraoka T, Saito Y, Matsuda T, Ikehara H, Gotoda T, Saito D, et al. Endoscopic indications for endoscopic mucosal resection of laterally spreading tumours in the colorectum. Gut 2006;55:1592-7.         [ Links ]

5. Vázquez-Sequeiros E, de Miquel DB, Foruny JR, González JA, García M, Juzgado D, et al. Training model for teaching endoscopic submucosal dissection of gastric tumors. Rev Esp Enferm Dig 2009;101(8):546-52.         [ Links ]

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