<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0003-3170</journal-id>
<journal-title><![CDATA[Angiología]]></journal-title>
<abbrev-journal-title><![CDATA[Angiología]]></abbrev-journal-title>
<issn>0003-3170</issn>
<publisher>
<publisher-name><![CDATA[Arán Ediciones S.L.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0003-31702023000200002</article-id>
<article-id pub-id-type="doi">10.20960/angiologia.00452</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Relación de los índices neutrófilo-linfocito y plaquetas-linfocito con desenlaces de severidad en isquemia aguda de miembros inferiores]]></article-title>
<article-title xml:lang="en"><![CDATA[Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio relation with outcomes in acute lower limb ischemia]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lagos-Castro]]></surname>
<given-names><![CDATA[Jenith Rocío]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lagos-Castro]]></surname>
<given-names><![CDATA[Katheryn Daniela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A5"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramírez-Herrán]]></surname>
<given-names><![CDATA[William]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Villada-Ochoa]]></surname>
<given-names><![CDATA[Óscar Alonso]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Camacho-Mazabuel]]></surname>
<given-names><![CDATA[María Alejandra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Antioquía Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Medellín ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,DIME. Clínica Neurocardiovascular  ]]></institution>
<addr-line><![CDATA[Santiago de Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Universitario San José  ]]></institution>
<addr-line><![CDATA[Popayán ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Clínica La Estancia  ]]></institution>
<addr-line><![CDATA[Popayán ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Universidad del Cauca Facultad de Ciencias de la Salud ]]></institution>
<addr-line><![CDATA[Popayán ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Hospital Alma Máter de Antioquia Servicio de Cirugía Vascular ]]></institution>
<addr-line><![CDATA[Medellín ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af7">
<institution><![CDATA[,Hospital San Vicente Fundación Dirección de Investigaciones ]]></institution>
<addr-line><![CDATA[Medellín ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2023</year>
</pub-date>
<volume>75</volume>
<numero>2</numero>
<fpage>67</fpage>
<lpage>77</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S0003-31702023000200002&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S0003-31702023000200002&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S0003-31702023000200002&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: los índices neutrófilos/linfocitos (NLR) y plaquetas/linfocitos (PLR) son marcadores de inflamación sistémica y podrían correlacionarse con amputación y muerte en pacientes con isquemia aguda de miembros inferiores.  Métodos: estudio retrospectivo, analítico y multicéntrico en una cohorte de pacientes con isquemia aguda de miembros inferiores no traumática ni iatrogénica entre 2017 y 2018. Se analizaron los datos clínicos y paraclínicos, se calcularon los NLR y los PLR al ingreso y se buscó su relación con la amputación y la muerte. Además, se realizó el seguimiento de dichos desenlaces hasta 24 meses después del evento.  Resultados: se identificaron 140 pacientes, 56 % de género masculino y con una edad media de 76 años. Un NLR &gt; 5,2 es un factor de riesgo para amputación intrahospitalaria (OR: 3,16) y para una menor supervivencia libre de amputación (HR: 3,75). Un NLR &gt; 8,4 es factor de riesgo para mortalidad intrahospitalaria (OR: 6,38) y para una supervivencia global menor (HR: 2,58). Por su parte, el PLR &gt; 208 se relaciona con una menor supervivencia libre de amputación (HR: 1,93) y un PLR &gt; 226 se correlaciona con una mortalidad intrahospitalaria mayor (OR 4,48) y es un factor de riesgo para una supervivencia global menor (HR: 2,33). Se encontró, además, que una clasificación de Rutherford IIb o III al ingreso, edad &gt; 60 años o antecedente de enfermedad renal crónica se asociaban con una mayor mortalidad intrahospitalaria.  Conclusiones: valores elevados en NLR y PLR se relacionan con un mayor riesgo de amputación y de mortalidad intrahospitalaria y con una menor supervivencia libre de amputación y supervivencia global en pacientes con isquemia aguda de extremidades inferiores, por lo que pueden usarse como una herramienta más a la hora de estadificar a los pacientes de alto riesgo que ingresan con dicho diagnóstico.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: neutrophil/lymphocyte (NLR) and platelet/lymphocyte (PLR) ratio are markers of systemic inflammation and may correlate with major outcomes in patients with acute lower limb ischemia.  Methods: a retrospective, analytic and multicenter study in a cohort of patients with acute lower limb ischemia, not traumatic or iatrogenic, between 2017 and 2018. Clinical and paraclinical data were analyzed, the NLR and PLR were calculated on admission and their relationship with amputation and death was sought. In addition, these outcomes were monitored up to 24 months after the event.  Results: 140 patients were identified, 56 % was male and they had a mean age of 76 years old. An NLR &gt; 5,2 is a risk factor for intra-hospital amputation (OR: 3,16) and for survival free of minor amputation (HR: 3,75). An NLR &gt; 8,4 is a risk factor for in-hospital mortality (OR: 6,38) and for a lower overall survival (HR: 2,58). Furthermore, PLR &gt; 208 is associated with a minor amputation-free survival (HR: 1,93) and a PLR &gt; 226 is correlated with greater hospital mortality (OR 4,48) and is a risk factor for a lower overall survival (HR: 2,33). It was also found that a classification of Rutherford IIb or III at admission, ages &gt; 60 years and/or history of chronic kidney disease were associated with higher intra-hospital mortality.  Conclusions: high values in the NLR and PLR are associated with increased risk of amputation and hospital mortality and are risk factors for free survival of amputation and reduced overall survival in patients with acute lower limb ischemia. Therefore, it can be used as one more tool when we're staging high-risk patients who are admitted with such a diagnosis.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Isquemia aguda]]></kwd>
<kwd lng="es"><![CDATA[Neutrófilo]]></kwd>
<kwd lng="es"><![CDATA[Plaqueta]]></kwd>
<kwd lng="es"><![CDATA[Linfocito]]></kwd>
<kwd lng="es"><![CDATA[Biomarcador]]></kwd>
<kwd lng="es"><![CDATA[Amputación]]></kwd>
<kwd lng="es"><![CDATA[Muerte]]></kwd>
<kwd lng="en"><![CDATA[Acute ischemia]]></kwd>
<kwd lng="en"><![CDATA[Neutrophil]]></kwd>
<kwd lng="en"><![CDATA[Platelet]]></kwd>
<kwd lng="en"><![CDATA[Lymphocyte]]></kwd>
<kwd lng="en"><![CDATA[Biomarker]]></kwd>
<kwd lng="en"><![CDATA[Amputation]]></kwd>
<kwd lng="en"><![CDATA[Death]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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