<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0003-3170</journal-id>
<journal-title><![CDATA[Angiología]]></journal-title>
<abbrev-journal-title><![CDATA[Angiología]]></abbrev-journal-title>
<issn>0003-3170</issn>
<publisher>
<publisher-name><![CDATA[Arán Ediciones S.L.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0003-31702023000200003</article-id>
<article-id pub-id-type="doi">10.20960/angiologia.00425</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Actualización de biomarcadores para la detección precoz de isquemia intestinal]]></article-title>
<article-title xml:lang="en"><![CDATA[Update on biomarkers for early detection of intestinal ischemia]]></article-title>
<article-title xml:lang="en"><![CDATA[Update on biomarkers for the early detection of intestinal ischemia]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Guerrero-González]]></surname>
<given-names><![CDATA[Enrique]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reyes-Valdivia]]></surname>
<given-names><![CDATA[Andrés]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ocaña-Guaita]]></surname>
<given-names><![CDATA[Julia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gandarias-Zúñiga]]></surname>
<given-names><![CDATA[Claudio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Universitario Ramón y Cajal Servicio de Angiología, Cirugía Vascular y Endovascular ]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2023</year>
</pub-date>
<volume>75</volume>
<numero>2</numero>
<fpage>78</fpage>
<lpage>84</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S0003-31702023000200003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S0003-31702023000200003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S0003-31702023000200003&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La isquemia intestinal asocia una elevada mortalidad debida principalmente a un retraso en el diagnóstico. Si bien el angio TC es una herramienta sensible y específica, suele transcurrir demasiado tiempo hasta su realización debido a una presentación clínica poco específica. En este tiempo la isquemia intestinal puede progresar a estadios irreversibles con afectación sistémica. La obtención de biomarcadores precisos y de elevación precoz acortaría el tiempo diagnóstico de esta patología, lo que disminuiría su mortalidad asociada. Se sabe que las moléculas usadas tradicionalmente, entre ellas el lactato, no tienen buena capacidad diagnóstica. No obstante, se ha observado una elevada sensibilidad con el uso del esteroisómero D del lactato y la procalcitonina para detectar colitis isquémica tras cirugía de aorta, al tiempo que se recomienda valorar los niveles de dímero D para descartar isquemia mesentérica aguda en pacientes con dolor abdominal. Otras moléculas con un potencial rendimiento diagnóstico son la proteína ligadora de ácidos grasos intestinales (I-FABP) y el péptido similar al glucagón de tipo 1 (GLP-1), aún en investigación.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Intestinal ischemia associates high mortality rates, mainly due to a delay in diagnosis. Although computed tomography angiography (CTA) remains a sensitive and specific tool, it usually takes quite long until it is done, due to an unspecific clinical presentation. In this time lapse, intestinal ischemia may progress to an irreversible stage with signs of systemic failure. The acquisition of precise and early detection biomarkers for the disease would shorten the time to diagnosis and hence its associated mortality. It is acknowledged that those molecules which have been classically used-lactate amongst them-do not have a proper diagnostic capacity. Nevertheless, the D stereoisomer of lactate and procalcitonin have shown high sensitivity for detection of ischemic colitis after open aortic surgery, while D-dimer measurement is recommended to rule out acute mesenteric ischemia in patients with abdominal pain. Other molecules with a potential for diagnostic yield are intestinal fatty acid binding protein (i-FABP) and glucagon-like peptide-1 (GLP-1), still under investigation.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Intestinal ischemia associates high mortality rates mainly due to delayed diagnoses. Although computed tomography angiography (CTA) remains a sensitive and specific tool, it often takes a long time to perform it in the presence of unspecific clinical presentations. In this time lapse, intestinal ischemia may progress into an irreversible stage with signs of systemic failure. The acquisition of precise and early detection biomarkers of the disease would shorten time to diagnosis and hence its associated mortality. It is widely accepted that the molecules that have traditionally been used &#8212;lactate among them&#8212; do not have proper diagnostic capabilities. Nevertheless, the D-stereoisomers of lactate and procalcitonin have shown high sensitivity rates for the detection of ischemic colitis after open aortic surgery while D-dimer measurement is recommended to rule out acute mesenteric ischemia in patients with abdominal pain. Other molecules with a potential for diagnostic yield that are still in the pipeline are intestinal fatty acid binding protein (i-FABP) and glucagon-like peptide-1 (GLP-1).]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Isquemia intestinal]]></kwd>
<kwd lng="es"><![CDATA[Isquemia mesentérica]]></kwd>
<kwd lng="es"><![CDATA[Colitis isquémica]]></kwd>
<kwd lng="es"><![CDATA[Biomarcadores]]></kwd>
<kwd lng="es"><![CDATA[D-lactato]]></kwd>
<kwd lng="es"><![CDATA[I-FABP]]></kwd>
<kwd lng="es"><![CDATA[GLP-1]]></kwd>
<kwd lng="en"><![CDATA[Intestinal ischaemia]]></kwd>
<kwd lng="en"><![CDATA[Mesenteric ischaemia]]></kwd>
<kwd lng="en"><![CDATA[Ischaemic colitis]]></kwd>
<kwd lng="en"><![CDATA[Biomarkers]]></kwd>
<kwd lng="en"><![CDATA[D-lactate]]></kwd>
<kwd lng="en"><![CDATA[I-FABP]]></kwd>
<kwd lng="en"><![CDATA[GLP-1]]></kwd>
<kwd lng="en"><![CDATA[Intestinal ischaemia]]></kwd>
<kwd lng="en"><![CDATA[Mesenteric ischemia]]></kwd>
<kwd lng="en"><![CDATA[Ischemic colitis]]></kwd>
<kwd lng="en"><![CDATA[Biomarkers]]></kwd>
<kwd lng="en"><![CDATA[D-lactate]]></kwd>
<kwd lng="en"><![CDATA[I-FABP]]></kwd>
<kwd lng="en"><![CDATA[GLP-1]]></kwd>
</kwd-group>
</article-meta>
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