<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0211-6995</journal-id>
<journal-title><![CDATA[Nefrología (Madrid)]]></journal-title>
<abbrev-journal-title><![CDATA[Nefrología (Madr.)]]></abbrev-journal-title>
<issn>0211-6995</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Española de Nefrología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0211-69952016000700643</article-id>
<article-id pub-id-type="doi">10.1016/j.nefro.2016.06.004</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Reno-protective effects of propolis on gentamicin-induced acute renal toxicity in swiss albino mice]]></article-title>
<article-title xml:lang="es"><![CDATA[Efectos renoprotectores del propóleo sobre la toxicidad renal aguda inducida por gentamicina en ratones albinos suizos]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aldahmash]]></surname>
<given-names><![CDATA[Badr Abdullah]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[El-Nagar]]></surname>
<given-names><![CDATA[Doaa Mohamed]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ibrahim]]></surname>
<given-names><![CDATA[Khalid Elfakki]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,King Saud University College of Science Department of Zoology]]></institution>
<addr-line><![CDATA[Riyadh ]]></addr-line>
<country>Saudi Arabia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Ain Shams University College of Girls for Science, Arts and Education Department of Zoology]]></institution>
<addr-line><![CDATA[Cairo ]]></addr-line>
<country>Egypt</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2016</year>
</pub-date>
<volume>36</volume>
<numero>6</numero>
<fpage>643</fpage>
<lpage>652</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S0211-69952016000700643&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S0211-69952016000700643&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S0211-69952016000700643&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background: Kidney is a vital organ which plays an important and irreplaceable role in detoxification and removal of xenobiotics. And therefore is vulnerable to develop various forms of injuries. Hence, making it immensely important to search for natural reno-protective compounds.  Objectives: This study therefore, aims to evaluate the reno-protective properties of propolis against gentamicin induced renal toxicity in mice.  Methods: Three groups of 10 male mice each were used for this study. First group served as control, the second group (Gm group) was administered orally 80 mg/kg body weight gentamicin for 7 days, and the third group (GmP group) was administered same dose of gentamicin with propolis (500 mg/kg body weight) for 7 days. Various parameters were used to study the renal toxicity.  Results: Gentamicin caused significant renal damage as evident by the rise in BUN levels, diminished glomeruli hypocellularity, moderately dilated tubules, and mild loss of brush border, severe infiltration, extensive tubular degeneration and presence of tubular cast. Histochemistry results show presence of collagen and reticular fibres. Immunohistochemical reactions show kidney injury (Kim-1 gene-expression), oxidative stress (MDA gene-expression), and an increase in apoptosis (caspase-3 gene-expression). Co-administration of propolis with gentamicin showed significant decrease in BUN levels, appearance of healthy glomeruli with normal cellularity, reduction of tubular injury, decrease of collagen and reticular fibres deposition, reduction of apoptosis, kidney injury and oxidative stress.  Conclusion: Results presented in this study clearly show the reno-protective role of propolis against gentamicin-induced toxicity on mice kidney.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Antecedentes: El riñón es un órgano vital que desempeña una función importante e insustituible en la desintoxicación y la eliminación de los xenobióticos y, por lo tanto, es vulnerable a desarrollar diversas formas de lesión. Esto hace muy importante la búsqueda de compuestos renoprotectores naturales.  Objetivos: Este estudio tiene como objetivo evaluar las propiedades renoprotectoras del propóleo contra la toxicidad renal inducida por gentamicina en ratones.  Métodos: Para este estudio se utilizaron 3 grupos de 10 ratones macho en cada uno. El primer grupo sirvió como control, el segundo grupo (grupo Gm) recibió 80 mg/kg de peso corporal de gentamicina por vía oral durante 7 días y el tercer grupo (grupo GmP) recibió la misma dosis de gentamicina con propóleo (500 mg/kg de peso corporal) durante 7 días. Se utilizaron varios parámetros para estudiar la toxicidad renal.  Resultados: La gentamicina causó daño renal significativo, como demostró el aumento de los niveles de nitrógeno ureico en sangre, la disminución de la hipocelularidad glomerular, los túbulos moderadamente dilatados y la pérdida leve del borde en cepillo, la infiltración grave, la degeneración tubular extensa y la presencia de cilindros tubulares. Los resultados de la histoquímica muestran presencia de colágeno y fibras reticulares. Las reacciones inmunohistoquímicas muestran lesión renal (expresión del gen Kim-1), estrés oxidativo (expresión del gen MDA) y un aumento de la apoptosis (expresión del gen caspasa-3). La administración concomitante de propóleo con gentamicina mostró disminución significativa de los niveles de nitrógeno ureico en la sangre, aspecto de glomérulos sanos con celularidad normal, reducción de la lesión tubular, disminución de colágeno y deposición de fibras reticulares, reducción de la apoptosis, daño renal y estrés oxidativo.  Conclusión: Los resultados presentados en este estudio muestran claramente la función renoprotectora del propóleo contra la toxicidad inducida por gentamicina en el riñón de los ratones.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Gentamicin]]></kwd>
<kwd lng="en"><![CDATA[Propolis]]></kwd>
<kwd lng="en"><![CDATA[Kidney]]></kwd>
<kwd lng="en"><![CDATA[Apoptosis]]></kwd>
<kwd lng="en"><![CDATA[Oxidative stress]]></kwd>
<kwd lng="es"><![CDATA[Gentamicina]]></kwd>
<kwd lng="es"><![CDATA[Propóleo]]></kwd>
<kwd lng="es"><![CDATA[Riñón]]></kwd>
<kwd lng="es"><![CDATA[Apoptosis]]></kwd>
<kwd lng="es"><![CDATA[Estrés oxidativo]]></kwd>
</kwd-group>
</article-meta>
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