<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0211-6995</journal-id>
<journal-title><![CDATA[Nefrología (Madrid)]]></journal-title>
<abbrev-journal-title><![CDATA[Nefrología (Madr.)]]></abbrev-journal-title>
<issn>0211-6995</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Española de Nefrología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0211-69952017000400370</article-id>
<article-id pub-id-type="doi">10.1016/j.nefro.2017.03.021</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Guía de práctica clínica sobre el diagnóstico y tratamiento de la hiponatremia]]></article-title>
<article-title xml:lang="en"><![CDATA[Hyponatraemia diagnosis and treatment clinical practice guidelines]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Spasovski]]></surname>
<given-names><![CDATA[Goce]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vanholder]]></surname>
<given-names><![CDATA[Raymond]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Allolio]]></surname>
<given-names><![CDATA[Bruno]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Annane]]></surname>
<given-names><![CDATA[Djillali]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A5"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ball]]></surname>
<given-names><![CDATA[Steve]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A6"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bichet]]></surname>
<given-names><![CDATA[Daniel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A7"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Decaux]]></surname>
<given-names><![CDATA[Guy]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fenske]]></surname>
<given-names><![CDATA[Wiebke]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hoorn]]></surname>
<given-names><![CDATA[Ewout J.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ichai]]></surname>
<given-names><![CDATA[Carole]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Joannidis]]></surname>
<given-names><![CDATA[Michael]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Soupart]]></surname>
<given-names><![CDATA[Alain]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zietse]]></surname>
<given-names><![CDATA[Robert]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Haller]]></surname>
<given-names><![CDATA[Maria]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Veer]]></surname>
<given-names><![CDATA[Sabine van der]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Biesen]]></surname>
<given-names><![CDATA[Wim van]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Nagler]]></surname>
<given-names><![CDATA[Evi]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gonzalez-Espinoza]]></surname>
<given-names><![CDATA[Liliana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A14"/>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ortiz]]></surname>
<given-names><![CDATA[Alberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A14"/>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,State University Hospital Skopje  ]]></institution>
<addr-line><![CDATA[Skopie ]]></addr-line>
<country>Macedonia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Ghent University Hospital  ]]></institution>
<addr-line><![CDATA[Ghent ]]></addr-line>
<country>Bélgica</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Würzburg University Hospital  ]]></institution>
<addr-line><![CDATA[Würzburg ]]></addr-line>
<country>Alemania</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Raymond Poincaré Hospital  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="A15">
<institution><![CDATA[,University of Versailles Saint Quentin  ]]></institution>
<addr-line><![CDATA[París ]]></addr-line>
<country>France</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Newcastle Hospitals  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="A16">
<institution><![CDATA[,Newcastle University  ]]></institution>
<addr-line><![CDATA[Newcastle ]]></addr-line>
<country>United Kingdom</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Sacré-Coeur Hospital  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="A17">
<institution><![CDATA[,University of Montreal  ]]></institution>
<addr-line><![CDATA[Montreal Quebec]]></addr-line>
<country>Canada</country>
</aff>
<aff id="Af7">
<institution><![CDATA[,Erasmus University Hospital  ]]></institution>
<addr-line><![CDATA[Bruselas ]]></addr-line>
<country>Bélgica</country>
</aff>
<aff id="Af8">
<institution><![CDATA[,Erasmus Medical Centre  ]]></institution>
<addr-line><![CDATA[Róterdam ]]></addr-line>
<country>Países Bajos</country>
</aff>
<aff id="Af9">
<institution><![CDATA[,Nice University Hospital  ]]></institution>
<addr-line><![CDATA[Niza ]]></addr-line>
<country>Francia</country>
</aff>
<aff id="A10">
<institution><![CDATA[,Innsbruck University Hospital  ]]></institution>
<addr-line><![CDATA[Innsbruck ]]></addr-line>
<country>Austria</country>
</aff>
<aff id="A11">
<institution><![CDATA[,KH Elisabethinen Linz  ]]></institution>
<addr-line><![CDATA[Linz ]]></addr-line>
<country>Austria</country>
</aff>
<aff id="A12">
<institution><![CDATA[,Amsterdam Medical Centre  ]]></institution>
<addr-line><![CDATA[Ámsterdam ]]></addr-line>
<country>Países Bajos</country>
</aff>
<aff id="A13">
<institution><![CDATA[,IIS-Fundación Jiménez Díaz  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="A18">
<institution><![CDATA[,Universidad Autónoma de Madrid Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>Spain</country>
</aff>
<aff id="A14">
<institution><![CDATA[,Fundación Renal Íñigo Álvarez de Toledo IRSIN REDINREN]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2017</year>
</pub-date>
<volume>37</volume>
<numero>4</numero>
<fpage>370</fpage>
<lpage>380</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S0211-69952017000400370&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S0211-69952017000400370&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S0211-69952017000400370&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La hiponatremia se define como una concentración sérica de sodio &lt;135 mmol/L y es el trastorno hidroelectrolítico más frecuente en la práctica clínica. La hiponatremia puede causar un amplio espectro de síntomas clínicos, desde sutiles hasta graves o incluso mortales, y se asocia con aumento de la morbimortalidad y prolongación de la estancia hospitalaria. A pesar de ello, el manejo de los pacientes con hiponatremia sigue siendo problemático. La prevalencia de hiponatremia en enfermedades muy diferentes y su manejo por muy diversos especialistas han fomentado la existencia de protocolos de diagnóstico y tratamiento muy diversos, que varían con la especialidad y la institución. La Sociedad Europea de Medicina Intensiva (ESICM), la Sociedad Europea de Endocrinología (ESE) y la Asociación Renal Europea-Asociación Europea de Diálisis y Trasplante (ERA-EDTA), representada por la European Renal Best Practices (ERBP), han desarrollado la guía de práctica clínica sobre el enfoque diagnóstico y tratamiento de la hiponatremia como una empresa conjunta de las 3 sociedades que representan a los especialistas con un interés natural en la hiponatremia, a fin de ofrecer una visión común y holística del abordaje del problema. Además de ofrecer un enfoque riguroso en la metodología y la evaluación de la evidencia, el documento está centrado en resultados importantes para el paciente y en facilitar una herramienta útil para los médicos en la práctica clínica cotidiana. Presentamos ahora una versión abreviada de las recomendaciones y sugerencias sobre el diagnóstico y el tratamiento de la hiponatremia recogidas en la guía completa.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Hyponatremia, defined as a serum sodium concentration &lt;135 mmol/l, is the most common water-electrolyte imbalance encountered in clinical practice. It can lead to a wide spectrum of clinical symptoms, from mild to severe or even life threatening, and is associated with increased mortality, morbidity and length of hospital stay. Despite this, the management of hyponatremia patients remains problematic. The prevalence of hyponatremia in a wide variety of conditions and the fact that hyponatremia is managed by clinicians with a broad variety of backgrounds have fostered diverse institution- and specialty-based approaches to diagnosis and treatment. To obtain a common and holistic view, the European Society of Intensive Care Medicine (ESICM), the European Society of Endocrinology (ESE) and the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA), represented by European Renal Best Practice (ERBP), have developed clinical practice guidelines on the diagnostic approach and treatment of hyponatremia as a joint venture of 3 societies representing specialists with a natural interest in hyponatremia. In addition to a rigorous approach to the methodology and evaluation of the evidence, the document focuses on patient-positive outcomes and on providing a useful tool for clinicians involved in everyday practice. In this article, we present an abridged version of the recommendations and suggestions for the diagnosis and treatment of hyponatremia extracted from the full guide.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Guía clínica]]></kwd>
<kwd lng="es"><![CDATA[Secreción inadecuada de ADH]]></kwd>
<kwd lng="es"><![CDATA[Hormona antidiurética]]></kwd>
<kwd lng="es"><![CDATA[Tolvaptan]]></kwd>
<kwd lng="es"><![CDATA[Síndrome de antidiuresis inapropiada]]></kwd>
<kwd lng="en"><![CDATA[Clinical guidelines]]></kwd>
<kwd lng="en"><![CDATA[SIADH]]></kwd>
<kwd lng="en"><![CDATA[Antidiuretic hormone]]></kwd>
<kwd lng="en"><![CDATA[Tolvaptan]]></kwd>
<kwd lng="en"><![CDATA[Syndrome of inappropriate antidiuretic hormone secretion]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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