<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0212-1611</journal-id>
<journal-title><![CDATA[Nutrición Hospitalaria]]></journal-title>
<abbrev-journal-title><![CDATA[Nutr. Hosp.]]></abbrev-journal-title>
<issn>0212-1611</issn>
<publisher>
<publisher-name><![CDATA[Grupo Arán]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0212-16112020000300020</article-id>
<article-id pub-id-type="doi">10.20960/nh.02846</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[El papel del resveratrol sobre el estrés oxidante inducido por metales pesados]]></article-title>
<article-title xml:lang="en"><![CDATA[The role of resveratrol on heavy metal-induced oxidative stress]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Nicolás-Méndez]]></surname>
<given-names><![CDATA[Tonancy]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ortiz-Muñiz]]></surname>
<given-names><![CDATA[Alda Rocío]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mendoza-Núñez]]></surname>
<given-names><![CDATA[Víctor Manuel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Rodríguez]]></surname>
<given-names><![CDATA[María del Carmen]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional Autónoma de México Facultad de Estudios Superiores Zaragoza Unidad de Investigación Genética y Toxicología Ambiental]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional Autónoma de México Facultad de Estudios Superiores Zaragoza Unidad de Investigación Gerontología]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Autónoma Metropolitana Iztapalapa Departamento de Ciencias de la Salud ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2020</year>
</pub-date>
<volume>37</volume>
<numero>2</numero>
<fpage>374</fpage>
<lpage>383</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S0212-16112020000300020&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S0212-16112020000300020&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S0212-16112020000300020&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción y objetivos: el estrés oxidante se considera uno de los principales mecanismos de genotoxicidad y carcinogenicidad de los metales pesados. Por otra parte, el resveratrol posee propiedades antioxidantes y es uno de los polifenoles más estudiados debido a su gran variedad de efectos benéficos para la salud. Sin embargo, no hay revisiones sistemáticas de la literatura científica en las que se analicen los efectos del resveratrol sobre el estrés oxidante inducido por metales pesados.  Métodos: en esta revisión se realizó una búsqueda de artículos mediante las bases de datos PubMed® y ScienceDirect® (1996-2018). Después de aplicar diversos filtros, se consideraron once investigaciones in vivo e in vitro en las que se estudiaron los efectos del resveratrol sobre el estrés oxidante inducido por el arsénico (As), el cadmio (Cd), el cobre (Cu), el cromo (Cr) y el hierro (Fe).  Resultados: en la revisión se presenta un análisis de los efectos químicos del resveratrol sobre el estrés oxidante asociado a la exposición a compuestos metálicos. Se discute la interacción del resveratrol con la producción de especies reactivas de oxígeno (ERO) y el sistema antioxidante endógeno, y sus efectos sobre el daño del ADN. A partir de estos estudios se genera un diagrama que muestra las interacciones propuestas para el resveratrol, los metales pesados As, Cd, Cu, Cr y Fe, y el estrés oxidante.  Conclusiones: los estudios analizados muestran que el resveratrol es capaz de modular el estrés oxidante generado por diferentes compuestos de metales pesados como As, Cd, Cu, Cr y Fe.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction and objectives: oxidative stress is considered one of the main mechanisms of genotoxicity and carcinogenicity of heavy metals. In contrast, resveratrol has antioxidant properties and is one of the most studied polyphenols due to its wide variety of beneficial health effects. However, there are no systematic reviews of the scientific literature in which the effects of resveratrol on oxidative stress induced by heavy metals are analyzed.  Methods: in this review, articles were searched using the PubMed® and ScienceDirect® databases (1996-2018). After applying various filters, eleven in vivo and in vitro researches were considered, in which the effects of resveratrol on oxidative stress as induced by arsenic (As), cadmium (Cd), copper (Cu), chromium (Cr) and iron (Fe) were studied.  Results: this review presents an analysis of the chemical effects of resveratrol on the oxidative stress associated with exposure to metal compounds. The interaction of resveratrol with the production of reactive oxygen species (ERO), the endogenous antioxidant system, and the effects on DNA damage are discussed. From these studies a diagram that shows the proposed interactions for resveratrol, heavy metals As, Cd, Cu, Cr and Fe, and oxidative stress is generated.  Conclusions: the studies analyzed show that resveratrol is able to modulate the oxidative stress generated by different heavy metal compounds such as As, Cd, Cu, Cr and Fe.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Polifenoles]]></kwd>
<kwd lng="es"><![CDATA[Antioxidantes]]></kwd>
<kwd lng="es"><![CDATA[Resveratrol]]></kwd>
<kwd lng="es"><![CDATA[Estrés oxidativo]]></kwd>
<kwd lng="es"><![CDATA[Metales pesados]]></kwd>
<kwd lng="en"><![CDATA[Polyphenols]]></kwd>
<kwd lng="en"><![CDATA[Antioxidants]]></kwd>
<kwd lng="en"><![CDATA[Resveratrol]]></kwd>
<kwd lng="en"><![CDATA[Oxidative stress]]></kwd>
<kwd lng="en"><![CDATA[Heavy metals]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Free radicals, metals and antioxidants in oxidative stress-induced cancer]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Valko]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Rhodes]]></surname>
<given-names><![CDATA[CJ]]></given-names>
</name>
<name>
<surname><![CDATA[Moncol]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Izakovic]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Mazur]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Chem Biol Interact]]></source>
<year>2006</year>
<volume>160</volume>
<page-range>1-40</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Oxidative stress and metal carcinogenesis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
<name>
<surname><![CDATA[Son]]></surname>
<given-names><![CDATA[YO]]></given-names>
</name>
<name>
<surname><![CDATA[Pratheeshkumar]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Shi]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
</person-group>
<source><![CDATA[Free Radic Biol Med]]></source>
<year>2012</year>
<volume>53</volume>
<page-range>742-57</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Laulicht]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Brocato]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Ke]]></surname>
<given-names><![CDATA[Q]]></given-names>
</name>
<name>
<surname><![CDATA[Costa]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Carcinogenicity of Metal Compounds]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Ke]]></surname>
<given-names><![CDATA[Q]]></given-names>
</name>
<name>
<surname><![CDATA[Kazantzis]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Costa]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Handbook on the Toxicology of Metals]]></source>
<year>2015</year>
<edition>4</edition>
<page-range>351-78</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Masindi]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Muedi]]></surname>
<given-names><![CDATA[KL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Environmental Contamination by Heavy Metals]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[El-Din M Saleh]]></surname>
<given-names><![CDATA[Hosam]]></given-names>
</name>
</person-group>
<source><![CDATA[Heavy Metals]]></source>
<year>2018</year>
<page-range>115-33</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Oxidative stress and apoptosis in metal ion-induced carcinogenesis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shi]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Hudson]]></surname>
<given-names><![CDATA[GL]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[KJ]]></given-names>
</name>
</person-group>
<source><![CDATA[Radic Biol Med]]></source>
<year>2004</year>
<volume>5</volume>
<page-range>582-93</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Advances in metal-induced oxidative stress and human disease]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jomova]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Valko]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Toxicology]]></source>
<year>2011</year>
<volume>283</volume>
<page-range>65-87</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Metals, toxicity and oxidative stress]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Valko]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Morris]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Cronin]]></surname>
<given-names><![CDATA[MTD]]></given-names>
</name>
</person-group>
<source><![CDATA[Curr Med Chem]]></source>
<year>2005</year>
<volume>12</volume>
<page-range>1161-208</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[García-Rodríguez]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
<name>
<surname><![CDATA[Altamirano-Lozano]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Gordillo-García]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Wong]]></surname>
<given-names><![CDATA[Janica]]></given-names>
</name>
</person-group>
<source><![CDATA[The Role of Green Tea Polyphenols in the Protection from Hexavalent Chromium-Induced Genotoxic Damage, Polyphenols]]></source>
<year>2018</year>
<page-range>51-67</page-range><publisher-loc><![CDATA[UK ]]></publisher-loc>
<publisher-name><![CDATA[IntechOpen]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Protective effect of curcumin against heavy metalsinduced liver damage]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[García-Niño]]></surname>
<given-names><![CDATA[WR]]></given-names>
</name>
<name>
<surname><![CDATA[Pedraza-Chaverrí]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[Food Chem Toxicol]]></source>
<year>2014</year>
<volume>69</volume>
<page-range>182-201</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Resveratrol attenuates oxidative stress in mitochondrial Complex I deficiency: Involvement of SIRT3]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mathieu]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Costa]]></surname>
<given-names><![CDATA[AL]]></given-names>
</name>
<name>
<surname><![CDATA[Le Bachelier]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Slama]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Lebre]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Taylor]]></surname>
<given-names><![CDATA[RW]]></given-names>
</name>
</person-group>
<source><![CDATA[Free Radic Biol and Med]]></source>
<year>2016</year>
<volume>96</volume>
<page-range>190-8</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Effects of resveratrol on 8-OHdG levels and endogenous antioxidants evaluated simultaneously with the micronucleus and apoptosis frequencies in peripheral blood of mice treated with hexavalent chromium]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[García-Rodríguez]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
<name>
<surname><![CDATA[Nicolás-Méndez]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Retana-Ugalde]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Altamirano-Lozano]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Journal of ISANH]]></source>
<year>2017</year>
<volume>5</volume>
<page-range>1-4</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Resveratrol and Oxidative Stress in Diabetes Mellitus]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Brasnyó]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Sümegi]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Winkler]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Wittmann]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<source><![CDATA[Diabetes: Oxidative Stress and Dietary Antioxidants]]></source>
<year>2014</year>
<page-range>99-109</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Multiplicity of effects and health benefits of resveratrol]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kur&#353;vietiene]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Staneviciene]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Mongirdiene]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Bernatoniene]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[Medicina (Kaunas)]]></source>
<year>2016</year>
<volume>52</volume>
<page-range>148-55</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Future directions of resveratrol research]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wahl]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Bernier]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Simpson]]></surname>
<given-names><![CDATA[SJ]]></given-names>
</name>
<name>
<surname><![CDATA[Cabo]]></surname>
<given-names><![CDATA[R de]]></given-names>
</name>
<name>
<surname><![CDATA[Le Couteur]]></surname>
<given-names><![CDATA[DG]]></given-names>
</name>
</person-group>
<source><![CDATA[Nutr Healthy Aging]]></source>
<year>2018</year>
<volume>15</volume>
<page-range>287-90</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Resveratrol induces apoptosis involving mitochondrial pathways in mouse skin tumorigenesis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kalra]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Roy]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Prasad]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Shukla]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<source><![CDATA[Life Sci]]></source>
<year>2008</year>
<volume>82</volume>
<page-range>348-58</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Resveratrol may protect plasma proteins from oxidation under conditions of oxidative stress in vitro]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pandey]]></surname>
<given-names><![CDATA[KB]]></given-names>
</name>
<name>
<surname><![CDATA[Rizvi]]></surname>
<given-names><![CDATA[SI]]></given-names>
</name>
</person-group>
<source><![CDATA[J Braz Chem Soc]]></source>
<year>2010</year>
<volume>2</volume>
<page-range>909-13</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Bioactive compounds in wine:Resveratrol, hydroxytyrosol and melatonin: A review]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fernández-Mar]]></surname>
<given-names><![CDATA[MI]]></given-names>
</name>
<name>
<surname><![CDATA[Mateos]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[García-Parrilla]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
<name>
<surname><![CDATA[Puertas]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Cantos-Villar]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<source><![CDATA[Food Chemistry]]></source>
<year>2012</year>
<volume>130</volume>
<page-range>797-813</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Dietary resveratrol confers apoptotic resistance to oxidative stress in myoblasts]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Haramizu]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Asano]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Butler]]></surname>
<given-names><![CDATA[DC]]></given-names>
</name>
<name>
<surname><![CDATA[David]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Stanton]]></surname>
<given-names><![CDATA[DA]]></given-names>
</name>
<name>
<surname><![CDATA[Hajira]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[J Nutr Biochem]]></source>
<year>2017</year>
<volume>50</volume>
<page-range>103-15</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Effects of Resveratrol against Lung Cancer: In Vitro and In Vivo Studies]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yousef]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Vlachogiannis]]></surname>
<given-names><![CDATA[IA]]></given-names>
</name>
<name>
<surname><![CDATA[Tsiani]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<source><![CDATA[Nutrients]]></source>
<year>2017</year>
<volume>10</volume>
<page-range>1-14</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Resveratrol: An overview of its anti-cancer mechanisms]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Elshaer]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[XJ]]></given-names>
</name>
<name>
<surname><![CDATA[Tang]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
</person-group>
<source><![CDATA[Life Sci]]></source>
<year>2018</year>
<volume>207</volume>
<page-range>340-9</page-range></nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Resveratrol promotes neuroprotection and attenuates oxidative and nitrosative stress in the small intestine in diabetic rats]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ferreira]]></surname>
<given-names><![CDATA[PEB]]></given-names>
</name>
<name>
<surname><![CDATA[Beraldi]]></surname>
<given-names><![CDATA[EJ]]></given-names>
</name>
<name>
<surname><![CDATA[Borges]]></surname>
<given-names><![CDATA[SC]]></given-names>
</name>
<name>
<surname><![CDATA[Natali]]></surname>
<given-names><![CDATA[MRM]]></given-names>
</name>
<name>
<surname><![CDATA[Buttow]]></surname>
<given-names><![CDATA[NC]]></given-names>
</name>
</person-group>
<source><![CDATA[Biomed Pharmacother]]></source>
<year>2018</year>
<volume>105</volume>
<page-range>724-33</page-range></nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Effect of resveratrol on lipid profile: An updated systematic review and meta-analysis on randomized clinical trials]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Haghighatdoost]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Hariri]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Pharmacol Res]]></source>
<year>2018</year>
<volume>129</volume>
<page-range>141-50</page-range></nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Drug delivery systems for resveratrol, a non-flavonoid polyphenol: Emerging evidence in last decades]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ahmadi]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Mohammadinejad]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Ashrafizadeh]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[J Drug Deliv Sci Technol]]></source>
<year>2019</year>
<volume>51</volume>
<page-range>591-604</page-range></nlm-citation>
</ref>
<ref id="B24">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Resveratrol: from enhanced biosynthesis and bioavailability to multitargeting chronic diseases]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pannu]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Bhatnagar]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Biomed Pharmacother]]></source>
<year>2019</year>
<volume>109</volume>
<page-range>2237-51</page-range></nlm-citation>
</ref>
<ref id="B25">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Therapeutic potential of resveratrol: the in vivo evidence]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Baur]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Sinclair]]></surname>
<given-names><![CDATA[DA]]></given-names>
</name>
</person-group>
<source><![CDATA[Nat Rev Drug Discov]]></source>
<year>2006</year>
<volume>5</volume>
<page-range>493-506</page-range></nlm-citation>
</ref>
<ref id="B26">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Neuroprotective action of resveratrol]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bastianetto]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Menard]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Quirion]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[Biochim Biophys Acta]]></source>
<year>2015</year>
<volume>1852</volume>
<page-range>1195-201</page-range></nlm-citation>
</ref>
<ref id="B27">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Occupational risk factors for nasopharyngeal cancer among female textile workers in Shanghai, China]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Ray]]></surname>
<given-names><![CDATA[RM]]></given-names>
</name>
<name>
<surname><![CDATA[Gao]]></surname>
<given-names><![CDATA[DL]]></given-names>
</name>
<name>
<surname><![CDATA[Fitzgibbons]]></surname>
<given-names><![CDATA[ED]]></given-names>
</name>
<name>
<surname><![CDATA[Seixas]]></surname>
<given-names><![CDATA[NS]]></given-names>
</name>
<name>
<surname><![CDATA[Camp]]></surname>
<given-names><![CDATA[JE]]></given-names>
</name>
</person-group>
<source><![CDATA[Occup Environ Med]]></source>
<year>2006</year>
<volume>63</volume>
<page-range>39-44</page-range></nlm-citation>
</ref>
<ref id="B28">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Biological Activities of Polyphenols from Grapes]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[En-Qin]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Gui-Fang]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Ya-Jun]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Hua-Bin]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<source><![CDATA[Int J Mol Sci]]></source>
<year>2010</year>
<volume>11</volume>
<page-range>622-46</page-range></nlm-citation>
</ref>
<ref id="B29">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Antioxidant and pro-oxidant actions of resveratrol on human serum albumin in the presence of toxic diabetes metabolites: Glyoxal and methyl-glyoxal]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Arcanjo]]></surname>
<given-names><![CDATA[NMO]]></given-names>
</name>
<name>
<surname><![CDATA[Luna]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Madruga]]></surname>
<given-names><![CDATA[MS]]></given-names>
</name>
<name>
<surname><![CDATA[Estévez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Biochim Biophys Acta Gen Dubi]]></source>
<year>2018</year>
<volume>1862</volume>
<page-range>1938-47</page-range></nlm-citation>
</ref>
<ref id="B30">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Resveratrol as an anti-cancer agent: A review]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rauf]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Imran]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Butt]]></surname>
<given-names><![CDATA[MS]]></given-names>
</name>
<name>
<surname><![CDATA[Nadeem]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Peters]]></surname>
<given-names><![CDATA[DG]]></given-names>
</name>
<name>
<surname><![CDATA[Mubarak]]></surname>
<given-names><![CDATA[MS]]></given-names>
</name>
</person-group>
<source><![CDATA[Crit Rev Food Sci Nutr]]></source>
<year>2018</year>
<volume>58</volume>
<page-range>1428-47</page-range></nlm-citation>
</ref>
<ref id="B31">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Resveratrol protects against arsenic trioxide-induced cardiotoxicity in vitro and in vivo]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhao]]></surname>
<given-names><![CDATA[XY]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[GY]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Chai]]></surname>
<given-names><![CDATA[LM]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[JX]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<source><![CDATA[Br J Pharmacol]]></source>
<year>2008</year>
<volume>154</volume>
<page-range>105-13</page-range></nlm-citation>
</ref>
<ref id="B32">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Dual role of resveratrol in modulation of genotoxicity induced by sodium arsenite via oxidative stress and apoptosis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Jiang]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Zhao]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
</person-group>
<source><![CDATA[Food Chem Toxicol]]></source>
<year>2013</year>
<volume>59</volume>
<page-range>8-17</page-range></nlm-citation>
</ref>
<ref id="B33">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Attenuation of arsenic retention by resveratrol in lung of arsenic trioxide-exposed rats]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Yao]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Ge]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Xue]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Ma]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<source><![CDATA[Environ Toxicol Pharmacol]]></source>
<year>2013</year>
<volume>36</volume>
<page-range>35-9</page-range></nlm-citation>
</ref>
<ref id="B34">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Resveratrol attenuates hepatotoxicity of rats exposed to arsenic trioxide]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Xue]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Ge]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Yu]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
</person-group>
<source><![CDATA[Food Chem Toxicol]]></source>
<year>2013</year>
<volume>51</volume>
<page-range>87-92</page-range></nlm-citation>
</ref>
<ref id="B35">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Comparative study of natural antioxidants - curcumin, resveratrol and melatonin- in cadmium-induced oxidative damage in mice]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Eybl]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Kotyzova]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Koutensky]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[Toxicology]]></source>
<year>2006</year>
<volume>225</volume>
<page-range>150-6</page-range></nlm-citation>
</ref>
<ref id="B36">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Resveratrol rescues cadmium-induced mitochondrial injury by enhancing transcriptional regulation of PGC-1a and SOD2 via the Sirt3/FoxO3a pathway in TCMK-1 cells]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fu]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Zhao]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Peng]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Wu]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<source><![CDATA[Biochem Biophys Res Commun]]></source>
<year>2017</year>
<volume>486</volume>
<page-range>198-204</page-range></nlm-citation>
</ref>
<ref id="B37">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Natural polyphenols may ameliorate damage induced by copper overload]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Arnal]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Tacconi de Alaniz]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
<name>
<surname><![CDATA[Marra]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
</person-group>
<source><![CDATA[Food Chem Toxicol]]></source>
<year>2012</year>
<volume>50</volume>
<page-range>415-22</page-range></nlm-citation>
</ref>
<ref id="B38">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[DNA oxidatively damaged by chromium (III) and H2O2 is protected by the antioxidants melatonin, N1-acetyl-N2-formyl-5-methoxykynuramine, resveratrol and uric acid]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Burkhardt]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Reiter]]></surname>
<given-names><![CDATA[RJ]]></given-names>
</name>
<name>
<surname><![CDATA[Tan]]></surname>
<given-names><![CDATA[DX]]></given-names>
</name>
<name>
<surname><![CDATA[Hardeland]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Cabrera]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Karbownik]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Int J Biochem Cell Biol]]></source>
<year>2001</year>
<volume>33</volume>
<page-range>775-83</page-range></nlm-citation>
</ref>
<ref id="B39">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Resveratrol protects the ovary against chromium-toxicity by enhancing endogenous antioxidant enzymes and inhibiting metabolic clearance of estradiol]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Banu]]></surname>
<given-names><![CDATA[SK]]></given-names>
</name>
<name>
<surname><![CDATA[Stanley]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Sivakumar]]></surname>
<given-names><![CDATA[KK]]></given-names>
</name>
<name>
<surname><![CDATA[Arosh]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Burghardt]]></surname>
<given-names><![CDATA[RC]]></given-names>
</name>
</person-group>
<source><![CDATA[Toxicol Appl Pharmacol]]></source>
<year>2016</year>
<volume>303</volume>
<page-range>65-78</page-range></nlm-citation>
</ref>
<ref id="B40">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Effects of dietary resveratrol on excess-iron-induced bone loss via antioxidative carácter]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhao]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Xu]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[Q]]></given-names>
</name>
<name>
<surname><![CDATA[Yin]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[J Nutr Biochem]]></source>
<year>2015</year>
<volume>26</volume>
<page-range>1174-82</page-range></nlm-citation>
</ref>
<ref id="B41">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Leonard]]></surname>
<given-names><![CDATA[SS]]></given-names>
</name>
<name>
<surname><![CDATA[Xia]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Jiang]]></surname>
<given-names><![CDATA[BH]]></given-names>
</name>
<name>
<surname><![CDATA[Stinefelt]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Klandorf]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Harris]]></surname>
<given-names><![CDATA[GK]]></given-names>
</name>
</person-group>
<source><![CDATA[Biochem Biophys Res Commun]]></source>
<year>2003</year>
<volume>309</volume>
<page-range>1017-26</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
