<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0212-1611</journal-id>
<journal-title><![CDATA[Nutrición Hospitalaria]]></journal-title>
<abbrev-journal-title><![CDATA[Nutr. Hosp.]]></abbrev-journal-title>
<issn>0212-1611</issn>
<publisher>
<publisher-name><![CDATA[Grupo Arán]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0212-16112020000600008</article-id>
<article-id pub-id-type="doi">10.20960/nh.03354</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Simbiosis en el tracto gastrointestinal humano]]></article-title>
<article-title xml:lang="en"><![CDATA[Symbiosis in the human gastrointestinal tract]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Guarner]]></surname>
<given-names><![CDATA[Francisco]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Vall d'Hebron Institut de Recerca Fisiología y Fisiopatología Digestiva ]]></institution>
<addr-line><![CDATA[Barcelona ]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2020</year>
</pub-date>
<volume>37</volume>
<numero>spe2</numero>
<fpage>34</fpage>
<lpage>37</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_arttext&amp;pid=S0212-16112020000600008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_abstract&amp;pid=S0212-16112020000600008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.isciii.es/scielo.php?script=sci_pdf&amp;pid=S0212-16112020000600008&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El cuerpo humano es un planeta poblado por miríadas de microorganismos en toda su superficie y en las cavidades conectadas con el exterior. La investigación experimental y clínica está demostrando que los colonizadores microbianos constituyen parte funcional y no prescindible del organismo humano. El ecosistema microbiano que se aloja en el tracto gastrointestinal aporta un "metagenoma": genes y funciones adicionales a los recursos genéticos de la especie, que participan en múltiples procesos fisiológicos (desarrollo somático, nutrición, inmunidad, etc.). El intestino humano alberga estructuras linfoides especializadas en la inducción y regulación de la inmunidad adaptativa. Asimismo, la interacción de la microbiota intestinal con el sistema inmunitario de la mucosa digestiva juega un papel clave para la homeostasis del individuo con el mundo exterior. Algunas enfermedades inflamatorias crónicas no transmisibles de la sociedad desarrollada se asocian a disbiosis: pérdida de riqueza de especies en la microbiota intestinal y desviación del entorno microbiano ancestral. Generar y mantener diversidad en la microbiota intestinal es un nuevo objetivo clínico para la promoción de salud y prevención de enfermedades.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The human body is a planet populated by myriads of microorganisms all over its surface and in cavities connected to the outside. Experimental and clinical research is showing that microbial colonizers are a functional and essential part of the human organism. The microbial ecosystem, which is housed in the gastrointestinal tract, provides a "metagenome": genes and additional functions to the genetic resources of the species, which are involved in multiple physiological processes (somatic development, nutrition, immunity, etc.). The human intestine houses lymphoid structures specialized in the induction and regulation of adaptive immunity, and the interaction of the intestinal microbiota with the immune system of the digestive mucosa plays a key role for the individual's homeostasis with the outside world. Some chronic non-communicable inflammatory diseases in developed society are associated with dysbiosis: loss of species richness in the gut microbiota and deviation from the ancestral microbial environment. Generating and maintaining diversity in the gut microbiota is a new clinical goal for health promotion and disease prevention.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Disbiosis]]></kwd>
<kwd lng="es"><![CDATA[Microbioma]]></kwd>
<kwd lng="es"><![CDATA[Microbiota]]></kwd>
<kwd lng="es"><![CDATA[Probióticos]]></kwd>
<kwd lng="es"><![CDATA[Prebióticos]]></kwd>
<kwd lng="en"><![CDATA[Dysbiosis]]></kwd>
<kwd lng="en"><![CDATA[Microbiome]]></kwd>
<kwd lng="en"><![CDATA[Microbiota]]></kwd>
<kwd lng="en"><![CDATA[Probiotics]]></kwd>
<kwd lng="en"><![CDATA[Prebiotics]]></kwd>
</kwd-group>
</article-meta>
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